Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Aminoglutethimide
Drug ID BADD_D00107
Description An aromatase inhibitor that produces a state of "medical" adrenalectomy by blocking the production of adrenal steroids. It also blocks the conversion of androgens to estrogens. Aminoglutethimide has been used in the treatment of advanced breast and prostate cancer. It was formerly used for its weak anticonvulsant properties. (From Martindale, The Extra Pharmacopoeia, 30th ed, p454)
Indications and Usage For the suppression of adrenal function in selected patients with Cushing's syndrome, malignant neoplasm of the female breast, and carcinoma in situ of the breast.
Marketing Status approved; investigational
ATC Code L02BG01
DrugBank ID DB00357
KEGG ID D00574
MeSH ID D000616
PubChem ID 2145
TTD Drug ID D0M6DO
NDC Product Code Not Available
UNII 0O54ZQ14I9
Synonyms Aminoglutethimide | Cytadren | Orimeten
Chemical Information
Molecular Formula C13H16N2O2
CAS Registry Number 125-84-8
SMILES CCC1(CCC(=O)NC1=O)C2=CC=C(C=C2)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Leukopenia01.02.02.001--Not Available
Malaise08.01.01.003--
Myalgia15.05.02.001--
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Pancytopenia01.03.03.003--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rhabdomyolysis15.05.05.002--
Seizure17.12.03.001--
Shock24.06.02.002--Not Available
Sinus tachycardia02.03.03.010--
Skin disorder23.03.03.007--Not Available
Somnolence17.02.04.006; 19.02.05.003--
Supraventricular tachycardia02.03.03.012--
Tachycardia02.03.02.007--Not Available
Tremor17.01.06.002--
Urticaria23.04.02.001; 10.01.06.001--
Vascular resistance systemic13.14.03.019--Not Available
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Virilism21.10.04.001; 05.05.01.001--
Vomiting07.01.07.003--
Haemodynamic instability24.03.02.006--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Precocious puberty05.05.03.001; 21.03.02.009--
Decreased appetite14.03.01.005; 08.01.09.028--
Pulmonary toxicity22.01.02.007; 12.03.01.013--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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