Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Amlodipine
Drug ID BADD_D00121
Description Amlodipine, initially approved by the FDA in 1987, is a popular antihypertensive drug belonging to the group of drugs called _dihydropyridine calcium channel blockers_. Due to their selectivity for the peripheral blood vessels, dihydropyridine calcium channel blockers are associated with a lower incidence of myocardial depression and cardiac conduction abnormalities than other calcium channel blockers [A175327]. Amlodipine is commonly used in the treatment of high blood pressure and angina. Amlodipine has antioxidant properties and an ability to enhance the production of nitric oxide (NO), an important vasodilator that decreases blood pressure [A175321]. The option for single daily dosing of amlodipine is an attractive feature of this drug [FDA label].
Indications and Usage Amlodipine may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of the following conditions [FDA label]: • Hypertension • Coronary artery disease • Chronic stable angina • Vasospastic angina (Prinzmetal’s or Variant angina) • Angiographically documented coronary artery disease in patients without heart failure or an ejection fraction < 40%
Marketing Status approved
ATC Code C08CA01
DrugBank ID DB00381
KEGG ID D07450
MeSH ID D017311
PubChem ID 2162
TTD Drug ID D08JIV
NDC Product Code 46287-035; 52652-5001; 69238-2026
UNII 1J444QC288
Synonyms Amlodipine | Amlodipine, (+-)-Isomer | Amlodipine Besylate | Amlodipine, (+-)-Isomer, Maleate (1:1) | Amlodipine, (S)-Isomer, Maleate (1:1) | Amlodis | Astudal | Norvasc | Istin | Amlor | Amlodipine Maleate | Amlodipine Maleate (1:1) | Amlodipine, (R)-Isomer
Chemical Information
Molecular Formula C20H25ClN2O5
CAS Registry Number 88150-42-9
SMILES CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000022%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000038%Not Available
Carotid artery stenosis17.08.02.001; 24.04.06.0010.000006%Not Available
Carotid artery thrombosis24.01.04.007; 17.08.01.0250.000006%Not Available
Cataract06.06.01.0010.000010%
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.000035%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000051%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.000089%
Chest discomfort22.12.02.002; 08.01.08.019; 02.02.02.0090.000039%Not Available
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.0020.000151%Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.12.03.0030.000006%Not Available
Cholelithiasis09.03.01.0020.000010%Not Available
Cholestasis09.01.01.001--Not Available
Chromaturia20.02.01.0020.000014%
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Circulatory collapse24.06.02.0010.000006%Not Available
Coagulopathy01.01.02.0010.000006%Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Colitis ischaemic24.04.08.012; 07.08.01.0040.000016%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000010%Not Available
Coma17.02.09.0010.000032%Not Available
Completed suicide19.12.01.001; 08.04.01.0100.000225%Not Available
Condition aggravated08.01.03.004--Not Available
Confusional state19.13.01.001; 17.02.03.0050.000065%
Conjunctival haemorrhage24.07.05.001; 06.07.01.0010.000010%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.001--
Coronary artery disease24.04.04.006; 02.02.01.0010.000057%Not Available
Coronary artery occlusion02.02.01.006; 12.02.01.036; 24.04.04.0130.000006%Not Available
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