Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Amoxicillin
Drug ID BADD_D00129
Description Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.[A190648] Amoxicillin has similar activity to [penicillin] and [ampicillin], but leads to higher serum concentrations than ampicillin.[A190648] Amoxicillin was granted FDA approval on 18 January 1974.[L11644]
Indications and Usage For the treatment of infections of the ear, nose, and throat, the genitourinary tract, the skin and skin structure, and the lower respiratory tract due to susceptible (only b-lactamase-negative) strains of Streptococcus spp. (a- and b-hemolytic strains only), S. pneumoniae, Staphylococcus spp., H. influenzae, E. coli, P. mirabilis, or E. faecalis. Also for the treatment of acute, uncomplicated gonorrhea (ano-genital and urethral infections) due to N. gonorrhoeae (males and females).
Marketing Status Prescription; Discontinued
ATC Code J01CA04
DrugBank ID DB01060
KEGG ID D00229
MeSH ID D000658
PubChem ID 33613
TTD Drug ID D0F6EO
NDC Product Code 16714-299; 63187-729; 68071-2323; 67296-1126; 70882-114; 63187-335; 50090-0407; 70518-1413; 70934-672; 50090-1826; 65862-016; 72789-225; 72789-077; 63187-186; 72189-285; 55657-106; 0093-3109; 68071-1526; 68071-4734; 45865-594; 65862-707; 68788-9949; 68071-1675; 50090-1794; 67296-1659; 61919-716; 68071-1817; 70847-530; 70882-113; 61919-041; 63187-044; 16714-298; 68071-4548; 50090-4260; 72508-205; 68071-2364; 63187-043; 68788-7318; 68071-4953; 65862-014; 50090-1797; 68071-2397; 65862-071; 52115-001; 65862-015; 0143-9889; 63187-200; 50090-4929; 63629-7585; 57237-033; 50090-1513; 70518-2191; 68071-4851; 68071-4704; 0143-9887; 50090-2251; 0781-5061; 63187-343; 0143-9886; 55289-182; 68071-4920; 70518-2188; 53002-1369; 68071-4567; 68071-4982; 50090-4320; 43063-820; 70934-064; 53002-2160; 0143-9888; 65862-274; 63629-7582; 71205-266; 63629-7584; 0093-4160; 50090-1795; 66267-871; 50090-0404; 0093-4161; 53002-0130; 50090-1807; 68071-1760; 0143-9938; 59115-041; 0143-9939; 68071-4907; 71205-507; 68788-7414; 76420-003; 65862-706; 0781-6156; 67296-1156; 68071-5019; 68071-4064; 63187-262; 68071-4455; 63187-195; 70518-3234; 43063-341; 68071-4574; 0781-5060; 72789-075; 61919-401; 65862-017; 68071-5127; 0781-6041; 57237-028; 43063-563; 68788-9017; 53002-2091; 70518-2190; 50090-0713; 63187-027; 68071-3292; 68071-4698; 68071-2604; 50090-3516; 43063-915; 70518-3228; 50090-1086; 63629-7587; 50090-1347; 53002-2080; 0093-2264; 70847-550; 68788-9948; 68071-2423; 63187-029; 68788-6374; 0093-2267; 68071-2558; 71205-422; 0781-6157; 70518-3294; 42708-112; 50090-1511; 50090-0712; 50090-1796; 55289-020; 43063-574; 50090-0709; 72789-074; 50090-0858; 68071-1789; 57237-030; 68071-4468; 68071-1761; 68071-3343; 63629-7589; 68071-4581; 70934-054; 70934-038; 70934-033; 0781-2613; 42708-078; 70934-087; 57237-031; 61919-015; 0093-3107; 54348-550; 55657-101; 61919-623; 72789-078; 63187-399; 66267-993; 68788-9019; 55289-019; 0781-2020; 71205-035; 42708-076; 68071-2320; 50090-0301; 71205-177; 50090-1595; 76420-138; 0093-2268; 53002-2090; 50090-1512; 0143-9285; 61919-994; 72789-224; 50090-1596; 68071-5148; 68788-7141; 68071-4971; 50090-0303; 66267-994; 50090-0405; 63187-880; 71205-436; 68071-4086; 0093-2263; 42708-010; 70934-140; 68788-6369; 61919-135; 50090-5863; 68788-9018; 57237-029; 50090-0455; 61919-672; 70934-084; 76420-192; 68071-4969; 65862-070; 72508-225; 70934-310; 68071-5096; 68071-5109; 50090-4078; 59651-099; 67296-0986; 68071-4741; 50090-5880; 63629-7588; 50090-4325; 70934-154; 50090-0711; 63187-013; 63187-295; 68071-4796; 43063-885; 0093-4155; 76420-112; 50090-0714; 57237-032; 63187-325; 68071-4693; 50090-0406; 43063-017; 68788-7812; 0781-6039; 50090-1514; 63187-591; 70934-407; 68071-3119; 50090-5215; 50090-0411; 68071-1826; 68071-4724; 68788-7323; 50090-0288; 68071-4696
Synonyms Amoxicillin | Amoxycillin | Amoxicilline | Amoxicillin Monopotassium Salt | Hydroxyampicillin | Amoxicillin Sodium | Amoxicillin Monosodium Salt | Amoxicillin, (R*)-Isomer | Amoxicillin Anhydrous | Actimoxi | BRL-2333 | BRL 2333 | BRL2333 | Clamoxyl | Penamox | Clamoxyl Parenteral | Clamoxyl G.A. | Polymox | Trimox | Wymox | Amoxicillin Trihydrate | Amoxil
Chemical Information
Molecular Formula C16H19N3O5S
CAS Registry Number 26787-78-0
SMILES CC1(C(N2C(S1)C(C2=O)NC(=O)C(C3=CC=C(C=C3)O)N)C(=O)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
HyperphosphatasaemiaC-C chemokine receptor type 4P51679T0695525998949
HyperphosphatasaemiaC-X-C chemokine receptor type 3P49682T2531525998949
HyperphosphatasaemiaC-C chemokine receptor type 9P51686T9787325998949
Liver injuryC-X-C chemokine receptor type 3P49682T2531525998949
Liver injuryC-C chemokine receptor type 9P51686T9787325998949
Liver injuryC-C chemokine receptor type 4P51679T0695525998949
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bradycardia02.03.02.002--Not Available
Bradycardia foetal18.03.02.006; 02.03.02.0180.000020%Not Available
Brain abscess17.06.07.001; 11.01.03.0030.000005%Not Available
Bronchiolitis22.03.02.004; 11.05.04.0080.000040%Not Available
Bronchitis22.07.01.001; 11.01.09.0010.000111%
Bronchospasm22.03.01.004; 10.01.03.0120.000353%
Bronchostenosis22.03.01.0200.000020%
Budd-Chiari syndrome24.01.03.001; 09.01.06.0010.000030%
Burning sensation17.02.06.001; 08.01.09.0290.000131%Not Available
C-reactive protein increased13.09.01.0070.000131%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiomegaly02.04.02.0010.000030%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cheilitis23.03.03.025; 07.05.01.0010.000050%
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.000222%Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.0010.000333%
Choking22.02.05.0010.000050%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.000081%Not Available
Cholangitis09.02.01.0020.000013%Not Available
Cholecystitis09.03.01.0010.000040%
Cholecystitis chronic09.03.01.0040.000020%Not Available
Cholestasis09.01.01.0010.000212%Not Available
Chromaturia20.02.01.0020.000232%
Circulatory collapse24.06.02.0010.000101%Not Available
Clonus17.02.05.0020.000020%Not Available
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