Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Anidulafungin
Drug ID BADD_D00143
Description Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin.
Indications and Usage For use in the treatment of the following fungal infections: Candidemia and other forms of Candida infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.
Marketing Status approved; investigational
ATC Code J02AX06
DrugBank ID DB00362
KEGG ID D03211
MeSH ID D000077612
PubChem ID 166548
TTD Drug ID D0F9BY
NDC Product Code 0009-0043; 11722-054; 0049-0114; 62227-007; 65727-072; 68254-0013; 0049-0116
UNII 9HLM53094I
Synonyms Anidulafungin | 1-((4R,5R)-4,5-Dihydroxy-N2-((4''-(pentyloxy)(1,1':4',1''-terphenyl)-4-yl)carbonyl)-L-ornithine)-echinocandin B | LY 303366 | LY303366 | LY-303366 | Eraxis
Chemical Information
Molecular Formula C58H73N7O17
CAS Registry Number 166663-25-8
SMILES CCCCCOC1=CC=C(C=C1)C2=CC=C(C=C2)C3=CC=C(C=C3)C(=O)NC4CC(C(NC(=O)C5C(C(CN5C(=O)C( NC(=O)C(NC(=O)C6CC(CN6C(=O)C(NC4=O)C(C)O)O)C(C(C7=CC=C(C=C7)O)O)O)C(C)O)C)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hyperkalaemia14.05.03.001--
Hypernatraemia14.05.04.001--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypokalaemia14.05.03.002--
Hypomagnesaemia14.04.02.001--
Hypotension24.06.03.002--
Hypoxia22.02.02.0030.000150%
Immune system disorder10.02.01.001--Not Available
Infection11.01.08.002--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia19.02.01.002; 17.15.03.002--
Lactic acidosis14.01.01.0020.000150%Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Lipase increased13.05.01.003--
Liver function test abnormal13.03.04.030--Not Available
Menopausal symptoms21.02.02.002--Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Neutropenia01.02.03.004--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Platelet count decreased13.01.04.001--
Pleural effusion22.05.02.002--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Prothrombin level increased13.01.02.011--Not Available
Prothrombin time prolonged13.01.02.012--Not Available
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