Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Apixaban
Drug ID BADD_D00151
Description Apixaban is an oral, direct, and highly selective factor Xa (FXa) inhibitor of both free and bound FXa, as well as prothrombinase, independent of antithrombin III for the prevention and treatment of thromboembolic diseases[Label,A6897]. It is marketed under the name Eliquis[Label,L6043]. Apixaban was approved by the FDA on December 28, 2012[L6043].
Indications and Usage Apixaban is indicated for reducing the risk of stroke and systemic embolism in patients who have nonvalvular atrial fibrillation, prophylaxis of deep vein thrombosis(DVT) leading to pulmonary embolism(PE) in patients after a hip or knee replacement surgery, and treatment of DVT and PE to reduce the risk of recurrence[Label,A177565,A6897].
Marketing Status approved
ATC Code B01AF02
DrugBank ID DB06605
KEGG ID D03213
MeSH ID C522181
PubChem ID 10182969
TTD Drug ID D0I5HF
NDC Product Code 0003-0893; 52048-0420; 69037-0023; 76397-007; 15308-1221; 24196-190; 58032-2028; 66174-0091; 50193-0893; 65372-1196; 65727-081; 0003-3764; 55154-0612; 59651-051; 70366-001; 14445-149; 12783-0893; 12783-0894; 17381-026; 42765-025; 42816-0894; 58623-0137; 63850-8085; 65129-1344; 66039-925; 66651-921; 69989-0006; 63629-7747; 12658-0440; 53869-0893; 73377-191; 55154-0613; 70518-1861; 71610-662; 67835-0015; 75945-060; 76397-010; 50090-6454; 82982-054; 14501-0089; 16436-0113; 65129-1465; 63629-8432; 14445-014; 53747-062; 53869-0894; 63415-0520; 65015-897; 76072-1017; 14445-150; 42816-0893; 0003-0894; 55111-980; 50090-6451
UNII 3Z9Y7UWC1J
Synonyms apixaban | Eliquis | BMS 562247 | BMS562247 | BMS-562247-01 | BMS-562247
Chemical Information
Molecular Formula C25H25N5O4
CAS Registry Number 503612-47-3
SMILES COC1=CC=C(C=C1)N2C3=C(CCN(C3=O)C4=CC=C(C=C4)N5CCCCC5=O)C(=N2)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchial obstruction22.03.01.0130.000043%
Calculus bladder20.04.03.0010.000174%Not Available
Calculus urinary20.04.03.0020.000117%Not Available
Capillary fragility23.06.04.002; 24.03.02.0010.000148%Not Available
Cardiac amyloidosis10.02.05.002; 02.04.01.0130.000108%Not Available
Cardiac failure02.05.01.0010.005449%
Cardiac failure acute02.05.01.0050.000291%Not Available
Cardiac tamponade02.06.01.0010.001801%
Cardiovascular disorder02.11.01.010; 24.03.02.0090.000456%Not Available
Carotid artery stenosis24.04.06.001; 17.08.02.0010.000347%Not Available
Carotid artery thrombosis24.01.04.007; 17.08.01.0250.000087%Not Available
Carpal tunnel syndrome17.09.02.0010.000390%Not Available
Cataract06.06.01.0010.001874%
Cerebellar infarction24.04.06.007; 17.08.01.0130.000239%Not Available
Cerebral artery embolism24.01.04.001; 17.08.01.0010.000824%Not Available
Cerebral artery occlusion24.04.06.020; 17.08.01.0280.000195%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.0030.013970%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.010933%Not Available
Cerebral ischaemia17.08.01.005; 24.04.06.0030.000390%
Cerebral thrombosis24.01.04.003; 17.08.01.0060.000282%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.031624%
Cerebrovascular disorder24.03.05.002; 17.08.02.0020.000291%Not Available
Cholangiocarcinoma16.07.01.002; 09.04.02.0090.000065%Not Available
Cholangitis09.02.01.0020.000195%Not Available
Cholecystitis09.03.01.0010.000347%
Cholestasis09.01.01.0010.000759%Not Available
Chromaturia20.02.01.0020.001367%
Chronic obstructive pulmonary disease22.03.01.0070.001419%Not Available
Clonus17.02.05.002--Not Available
Coagulopathy01.01.02.0010.000898%Not Available
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