Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bicalutamide
Drug ID BADD_D00271
Description Bicalutamide is an oral non-steroidal anti-androgen for prostate cancer. It is comprised of a racemic mixture that is a 50:50 composition of the (R)-bicalutamide and (S)-bicalutamide enantionmers. Bicalutamide binds to the androgen receptor.
Indications and Usage For treatment (together with surgery or LHRH analogue) of advanced prostatic cancer.
Marketing Status Prescription; Discontinued
ATC Code L02BB03
DrugBank ID DB01128
KEGG ID D00961
MeSH ID C053541
PubChem ID 2375
TTD Drug ID D0V9BD
NDC Product Code 60429-177; 70518-2993; 51846-1028; 16714-816; 62559-680; 0904-6019; 16729-023; 43265-0705; 15308-0360; 54893-0001; 49711-1504; 65841-613; 43265-7195; 49711-1509; 71205-577; 68382-224; 47335-485; 63629-8308; 63759-0004; 62559-890; 53104-7664; 46014-1111; 58623-0068
Synonyms bicalutamide | 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide | Casodex | Cosudex | ICI-176334 | ICI 176334
Chemical Information
Molecular Formula C18H14F4N2O4S
CAS Registry Number 90357-06-5
SMILES CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood sodium decreased13.11.01.0120.009667%Not Available
Blood testosterone decreased13.10.05.0040.006444%Not Available
Blood testosterone increased13.10.05.0020.032222%Not Available
Blood urea increased13.13.01.0060.012889%Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.004--Not Available
Bone pain15.02.01.0010.016111%
Bradycardia02.03.02.0020.016111%Not Available
Breast pain21.05.05.003--
Breast swelling21.05.05.0080.009667%Not Available
Breast tenderness21.05.05.004--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bundle branch block right02.03.01.0110.006444%Not Available
Cachexia16.32.03.011; 14.03.02.001; 08.01.01.0090.001681%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.017652%
Cardiac failure congestive02.05.01.0020.038667%Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiomegaly02.04.02.0010.003362%Not Available
Cardiomyopathy02.04.01.0010.002522%Not Available
Carotid artery stenosis17.08.02.001; 24.04.06.0010.006444%Not Available
Cataract06.06.01.0010.012889%
Cellulitis23.09.01.001; 11.02.01.0010.016111%Not Available
Cerebellar syndrome17.02.02.0020.006444%Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.0010.003362%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.054778%Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.0050.003362%
Cerebral thrombosis24.01.04.003; 17.08.01.0060.006444%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
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