Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
UNII Y41JS2NL6U
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nodal rhythm02.03.03.0210.001256%Not Available
Oedema14.05.06.010; 08.01.07.0060.001099%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.003830%
Oligohydramnios18.05.01.0010.000314%Not Available
Orthopnoea02.11.05.010; 22.02.01.0200.000785%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.0200.001727%Not Available
Osteoarthritis15.01.04.001--Not Available
Overdose12.11.01.002--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.11.04.0120.007535%
Pancreatitis acute07.18.01.0020.001727%Not Available
Panic attack19.06.04.0010.000628%Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Paresis17.01.04.008--Not Available
Pemphigoid23.03.01.004; 10.04.02.0020.000942%Not Available
Peptic ulcer07.04.07.001--Not Available
Pericardial effusion02.06.01.0020.001162%
Pericardial haemorrhage24.07.01.013; 02.06.01.0030.000628%Not Available
Pericarditis02.06.02.0010.000471%
Peripheral coldness23.06.04.008; 24.04.03.006; 08.01.09.0100.001570%Not Available
Peripheral ischaemia24.04.03.002--
Peyronie's disease21.12.01.002--Not Available
Pharyngitis11.01.13.003; 22.07.03.004; 07.05.07.004--
Photosensitivity reaction23.03.09.0030.000471%
Pleural effusion22.05.02.0020.002826%
Pleurisy22.05.01.0010.000314%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumothorax22.05.02.0030.000471%
Polycythaemia01.07.01.0010.000314%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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