Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Bisoprolol
Drug ID BADD_D00277
Description Bisoprolol is a cardioselective β1-adrenergic blocking agent used to treat high blood pressure.[A180472,L7219] It is considered a potent drug with a long-half life that can be used once daily to reduce the need for multiple doses of antihypertensive drugs.[A180472] Bisoprolol is generally well tolerated, likely due to its β1-adrenergic receptor selectivity and is a useful alternative to non-selective β-blocker drugs in the treatment of hypertension such as [Carvedilol] and [Labetalol]. It may be used alone or in combination with other drugs to manage hypertension[L7219] and can be useful in patients with chronic obstructive pulmonary disease (COPD) due to its receptor selectivity.[A180562]
Indications and Usage Bisoprolol is indicated for the treatment of mild to moderate hypertension.[L7219] It may be used off-label to treat heart failure, atrial fibrillation, and angina pectoris.[A180460,A180463]
Marketing Status approved
ATC Code C07AB07
DrugBank ID DB00612
KEGG ID D02342
MeSH ID D017298
PubChem ID 2405
TTD Drug ID D0K3ZR
NDC Product Code Not Available
UNII Y41JS2NL6U
Synonyms Bisoprolol | Bisoprolol Fumarate (1:1) Salt, (+-)-Isomer | Bisoprolol Fumarate (2:1) Salt, (+-)-Isomer | Bisoprolol Hydrochloride | Hydrochloride, Bisoprolol | Bisoprolol Methanesulfonate Salt | Bisoprolol, (+-)-Isomer | Bisoprolol, Fumarate (1:1) Salt | Bisoprolol, Fumarate (2:1) Salt | CL-297939 | CL 297939 | CL297939 | Concor | EMD-33512 | EMD 33512 | EMD33512 | Bisoprolol Fumarate | Fumarate, Bisoprolol | Bisoprolol, (-)-Isomer
Chemical Information
Molecular Formula C18H31NO4
CAS Registry Number 66722-44-9
SMILES CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Retrograde ejaculation21.03.01.0060.000942%Not Available
Rhinitis22.07.03.006; 11.01.13.004--
Rhinitis allergic22.04.04.003; 10.01.04.003--
Rhinorrhoea22.12.03.0210.001099%
Right ventricular failure02.05.03.0020.000314%Not Available
Scleroderma10.04.07.001; 23.03.02.005; 15.06.01.002--Not Available
Sense of oppression08.01.09.0200.000471%Not Available
Shock24.06.02.0020.001256%Not Available
Sinoatrial block02.03.01.0100.002198%Not Available
Sinus arrest02.03.03.0070.000628%Not Available
Sinus bradycardia02.03.03.0090.009262%
Sinus tachycardia02.03.03.0100.000942%
Sinusitis22.07.03.007; 11.01.13.005--
Sjogren's syndrome15.06.01.015; 07.06.01.010; 06.08.02.011; 10.04.04.0090.000314%Not Available
Skin cancer23.08.02.002; 16.03.02.0020.000471%Not Available
Skin discolouration23.03.03.0050.000785%Not Available
Skin disorder23.03.03.007--Not Available
Skin fissures23.03.03.0080.000471%Not Available
Skin hyperpigmentation23.05.01.003--
Skin irritation23.03.04.009--Not Available
Skin reaction10.01.03.019; 23.03.03.0130.000942%Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Sleep apnoea syndrome22.02.01.013; 19.02.05.002; 17.15.05.0010.000471%
Sleep disorder19.02.04.0010.002732%Not Available
Sleep paralysis19.02.02.004; 17.15.02.0050.000314%Not Available
Sneezing22.12.03.0240.000628%
Somnolence19.02.05.003; 17.02.04.0060.004553%
Speech disorder19.19.02.002; 17.02.08.003; 22.12.03.0270.000785%Not Available
Stillbirth18.01.02.002; 08.04.01.006--Not Available
Stress19.06.02.0040.001005%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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