Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabazitaxel
Drug ID BADD_D00328
Description Cabazitaxel is an anti-neoplastic used with the steroid medicine prednisone. Cabazitaxel is used to treat people with prostate cancer that has progressed despite treatment with docetaxel. Cabazitaxel is prepared by semi-synthesis with a precursor extracted from yew needles (10-deacetylbaccatin III). It was approved by the U.S. Food and Drug Administration (FDA) on June 17, 2010.
Indications and Usage For treatment of patients with hormone-refractory metastatic prostate cancer previously treated with a docetaxel-containing treatment regimen.
Marketing Status approved
ATC Code L01CD04
DrugBank ID DB06772
KEGG ID D09755
MeSH ID C552428
PubChem ID 9854073
TTD Drug ID D02HSB
NDC Product Code 54893-0016; 61200-101; 0024-5824; 47848-044; 63126-909; 55111-962; 68554-0080
UNII 51F690397J
Synonyms cabazitaxel | kabazitaxel | Jevtana
Chemical Information
Molecular Formula C45H57NO14
CAS Registry Number 183133-96-2
SMILES CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O) O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)OC)C)OC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Peripheral sensory neuropathy17.09.03.005--
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pollakiuria20.02.02.007--
Pyrexia08.05.02.003--
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Renal colic20.02.03.010--
Renal failure20.01.03.005--Not Available
Sciatica17.10.03.001; 15.10.01.001--Not Available
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Skin disorder23.03.03.007--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
Ureteric obstruction20.06.01.005--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary incontinence17.05.01.008; 20.02.02.010--
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Ventricular fibrillation02.03.04.008--
Vertigo17.02.12.002; 04.04.01.003--
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Neutropenic sepsis11.01.11.006; 01.02.03.007--Not Available
Musculoskeletal chest pain22.09.01.001; 15.03.04.012--
Deep vein thrombosis24.01.02.003--Not Available
Malignant neoplasm progression16.16.01.005--Not Available
Lymphatic disorder01.09.01.003--Not Available
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