Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status approved
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 59762-1005; 47848-009; 14096-153; 23155-823; 70512-860; 50090-5834; 0093-5420; 50742-118
UNII LL60K9J05T
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ovarian enlargement21.11.02.0010.007207%Not Available
Ovarian hyperstimulation syndrome21.11.02.007; 05.05.01.0130.033631%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.033150%
Palpitations02.11.04.012--
Panic attack19.06.04.0010.007207%Not Available
Paraesthesia23.03.03.094; 17.02.06.005--
Pericardial effusion02.06.01.002--
Pericarditis02.06.02.001--
Pericarditis constrictive02.06.02.002--Not Available
Periorbital oedema23.04.01.002; 10.01.05.010; 06.08.03.017--
Pituitary tumour16.24.01.003; 05.03.05.0020.009609%Not Available
Pleural effusion22.05.02.0020.009609%
Pleural fibrosis22.05.03.003--Not Available
Pleurisy22.05.01.001--Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pre-existing condition improved08.01.03.0430.010570%Not Available
Premature baby18.04.02.0010.014413%Not Available
Premature delivery18.07.01.0060.004804%
Premature separation of placenta18.02.01.004; 24.07.03.0190.004804%Not Available
Priapism24.04.12.007; 21.03.01.0050.019218%Not Available
Prostatic disorder21.04.01.001--Not Available
Pruritus23.03.12.001--
Psychomotor hyperactivity17.01.02.011; 19.11.02.0030.004804%Not Available
Pulmonary fibrosis22.01.02.0060.007207%
Pulmonary hypertension24.08.03.002; 22.06.01.0010.009609%
Rash23.03.13.001--Not Available
Raynaud's phenomenon24.04.03.0030.019218%Not Available
Respiratory acidosis22.02.02.004; 14.01.04.0020.007207%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.004804%
The 6th Page    First    Pre   6 7 8 9 10    Next   Last    Total 10 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene