Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cabergoline
Drug ID BADD_D00329
Description Cabergoline, an ergot derivative, is a long-acting dopamine agonist and prolactin inhibitor. It is used to treat hyperprolactinemic disorders and Parkinsonian Syndrome. Cabergoline possesses potent agonist activity on dopamine D2 receptors.
Indications and Usage For the treatment of hyperprolactinemic disorders, either idiopathic or due to prolactinoma (prolactin-secreting adenomas). May also be used to manage symptoms of Parkinsonian Syndrome as monotherapy during initial symptomatic management or as an adjunct to levodopa therapy during advanced stages of disease.
Marketing Status approved
ATC Code G02CB03; N04BC06
DrugBank ID DB00248
KEGG ID D00987
MeSH ID D000077465
PubChem ID 54746
TTD Drug ID D04EGX
NDC Product Code 40016-011; 59762-1005; 47848-009; 14096-153; 23155-823; 70512-860; 50090-5834; 0093-5420; 50742-118
UNII LL60K9J05T
Synonyms Cabergoline | 1-((6-allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea | FCE 21336 | FCE-21336 | Cabaser | Cabaseril | Dostinex | Galastop | Cabergoline Diphosphate | 1-Ethyl-2-(3'-dimethylaminopropyl)-3-(6'-allylergoline-8'-beta-carbonyl)urea diphosphate
Chemical Information
Molecular Formula C26H37N5O2
CAS Registry Number 81409-90-7
SMILES CCNC(=O)N(CCCN(C)C)C(=O)C1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)CC=C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Coronary artery dissection12.02.01.035; 24.02.02.001; 02.02.01.0040.021620%Not Available
Paradoxical drug reaction08.06.01.0140.007207%Not Available
Peripheral swelling08.01.03.053; 02.05.04.0150.015374%Not Available
Tumour haemorrhage24.07.01.028; 16.32.03.0080.004804%
Pituitary haemorrhage05.03.04.005; 24.07.04.009; 17.08.01.0190.028826%Not Available
Bradyarrhythmia02.03.02.0150.004804%Not Available
Balance disorder08.01.03.081; 17.02.02.0070.009609%Not Available
Sudden onset of sleep17.15.04.003--Not Available
Ventricular hypokinesia02.04.02.0130.009609%Not Available
Self-injurious ideation19.12.01.0070.004804%Not Available
Central nervous system lesion17.02.10.0110.007207%Not Available
Musculoskeletal stiffness15.03.05.0270.004804%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Foetal death18.01.02.003; 08.04.01.0110.007207%
Bipolar disorder19.16.01.0030.007207%Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.0010.004804%Not Available
Disturbance in sexual arousal19.08.04.003--Not Available
Drug resistance08.06.01.0050.031229%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Brain neoplasm17.20.01.003; 16.30.01.0030.004804%Not Available
Cardiac disorder02.11.01.003--Not Available
Impulse-control disorder19.18.01.0020.016815%Not Available
Ischaemic stroke24.04.06.010; 17.08.01.0180.004804%Not Available
Neoplasm progression16.16.02.0050.028826%Not Available
Optic neuropathy17.04.05.005; 06.02.08.0020.004804%Not Available
Cardiac valve disease02.07.02.0010.021620%Not Available
Visual pathway disorder17.17.01.021; 06.02.08.0040.016815%Not Available
Abnormal behaviour19.01.01.0010.004804%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Ill-defined disorder08.01.03.049--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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