| Drug Name |
Captopril |
| Drug ID |
BADD_D00354 |
| Description |
Captopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension. |
| Indications and Usage |
For the treatment of essential or renovascular hypertension (usually administered with other drugs, particularly thiazide diuretics). May be used to treat congestive heart failure in combination with other drugs (e.g. cardiac glycosides, diuretics, β-adrenergic blockers). May improve survival in patients with left ventricular dysfunction following myocardial infarction. May be used to treat nephropathy, including diabetic nephropathy. |
| Marketing Status |
approved |
| ATC Code |
C09AA01 |
| DrugBank ID |
DB01197
|
| KEGG ID |
D00251
|
| MeSH ID |
D002216
|
| PubChem ID |
44093
|
| TTD Drug ID |
D0I0EG
|
| NDC Product Code |
27241-162; 31722-141; 31722-142; 0143-1171; 63629-8728; 69292-526; 53296-0031; 31722-144; 0143-1174; 60687-304; 63629-1338; 63629-8730; 0781-8061; 0904-7105; 63629-8729; 70518-3307; 71335-1918; 51552-1072; 51927-0137; 27241-160; 27241-161; 43547-363; 63629-8727; 69292-522; 71335-0826; 0781-8052; 53069-0150; 31722-143; 27241-163; 51407-601; 51407-602; 51407-603; 43547-366; 55289-344; 0781-8080; 55488-0600; 43547-364; 0781-8075; 0143-1172; 0143-1173; 43547-365; 50090-5964; 51407-600; 60687-315; 69292-524; 69292-528; 0904-7106 |
| UNII |
9G64RSX1XD
|
| Synonyms |
Captopril | (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline | Lopirin | SQ-14,534 | SQ 14,534 | SQ14,534 | SQ-14534 | SQ 14534 | SQ14534 | Capoten | SQ-14,225 | SQ 14,225 | SQ14,225 | SQ-14225 | SQ 14225 | SQ14225 |
