Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Carboplatin
Drug ID BADD_D00364
Description Carboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma.[L32253] Early clinical studies of carboplatin were performed in 1982.[A230523] Carboplatin was developed as an analog of [cisplatin] with reduced nephrotoxicity and vomiting.[A230463,A230523] Carboplatin was granted FDA approval on 3 March 1989.[L32248]
Indications and Usage For the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents. One established combination regimen consists of PARAPLATIN and cyclophosphamide. It is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior chemotherapy, including patients who have been previously treated with cisplatin.
Marketing Status Prescription; Discontinued
ATC Code L01XA02
DrugBank ID DB00958
KEGG ID D01363
MeSH ID D016190
PubChem ID 426756
TTD Drug ID D0X7HM
NDC Product Code 0703-4239; 55150-335; 63592-0271; 68083-192; 49812-0010; 68554-0084; 53104-7570; 69448-005; 0703-4246; 54875-0002; 55150-386; 55150-334; 0703-4248; 55150-333; 63323-172; 72659-863; 68083-191; 71288-100; 16729-295; 0703-4244; 68083-193; 68083-190; 61703-339
Synonyms Carboplatin | cis-Diammine(cyclobutanedicarboxylato)platinum II | CBDCA | Paraplatin | Paraplatine | Platinwas | Ribocarbo | Carboplat | Neocarbo | Carbosin | Carbotec | Ercar | JM-8 | JM 8 | JM8 | Nealorin | NSC-241240 | NSC 241240 | NSC241240 | Blastocarb
Chemical Information
Molecular Formula C6H12N2O4Pt
CAS Registry Number 41575-94-4
SMILES C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cellulitis23.09.01.001; 11.02.01.0010.002931%Not Available
Cerebral artery embolism24.01.04.001; 17.08.01.0010.000139%Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.016784%Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.017317%Not Available
Chest X-ray abnormal13.19.02.0010.000533%Not Available
Chills15.05.03.016; 08.01.09.0010.014120%
Choking22.02.05.0010.000533%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.000533%Not Available
Cholecystitis09.03.01.0010.000533%
Cholestasis09.01.01.0010.001332%Not Available
Cholinergic syndrome17.05.01.0020.001332%Not Available
Chromaturia20.02.01.0020.001066%
Chronic myeloid leukaemia01.10.07.001; 16.01.07.0010.001332%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000903%Not Available
Circulatory collapse24.06.02.0010.002131%Not Available
Clostridium difficile colitis07.19.01.004; 11.02.02.0040.001598%Not Available
Cold sweat23.02.03.002; 08.01.03.0240.003463%Not Available
Colitis07.08.01.0010.000834%
Colitis ischaemic07.08.01.004; 24.04.08.0120.001598%Not Available
Coma17.02.09.001--Not Available
Compartment syndrome24.04.05.006; 15.05.05.0050.000533%Not Available
Confusional state19.13.01.001; 17.02.03.0050.007992%
Constipation07.02.02.001--
Coronary artery occlusion24.04.04.013; 02.02.01.0060.000533%Not Available
Cough22.02.03.0010.020247%
Cyanosis02.01.02.002; 24.03.01.007; 22.02.02.0070.004263%
Cystitis20.03.02.002; 11.01.14.0010.001865%
The 4th Page    First    Pre   4 5 6 7 8    Next   Last    Total 25 Pages