Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cefazolin
Drug ID BADD_D00382
Description A semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. It attains high serum levels and is excreted quickly via the urine.
Indications and Usage Mainly used to treat bacterial infections of the skin. It can also be used to treat moderately severe bacterial infections involving the lung, bone, joint, stomach, blood, heart valve, and urinary tract. It is clinically effective against infections caused by staphylococci and streptococci species of Gram positive bacteria. May be used for surgical prophylaxis; if required metronidazole may be added to cover B. fragilis.
Marketing Status approved
ATC Code J01DB04
DrugBank ID DB01327
KEGG ID D02299
MeSH ID D002437
PubChem ID 33255
TTD Drug ID D09KDN
NDC Product Code 0409-2585; 0143-9923; 0781-3451; 0404-9833; 72572-055; 60505-6231; 0781-3450; 60505-6142; 60505-6143; 71872-7027; 44567-707; 44567-840; 52584-924; 71205-679; 72572-056; 60505-6243; 17337-0300; 0143-9924; 44567-120; 52584-087; 60505-6244; 67184-0560; 67184-1001; 0404-9835; 44567-706; 52584-923; 70518-3047; 0143-9262; 0404-9834; 71872-7141; 0781-3452; 0143-9139; 0143-9140; 0143-9261; 0143-9665; 0143-9983; 44567-708
UNII IHS69L0Y4T
Synonyms Cefazolin | Cephazolin | Cefamedin | Cefamezine | Cephamezine | Gramaxin | Kefzol | Totacef | Ancef | Cefazolin Sodium | Sodium, Cefazolin | Sodium Cephazolin | Cephazolin, Sodium | Cephazolin Sodium | Sodium, Cephazolin
Chemical Information
Molecular Formula C14H14N8O4S3
CAS Registry Number 25953-19-9
SMILES CC1=NN=C(S1)SCC2=C(N3C(C(C3=O)NC(=O)CN4C=NN=N4)SC2)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.000049%Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Pneumonia streptococcal22.07.06.006; 11.02.06.005--Not Available
Premature baby18.04.02.0010.000097%Not Available
Premature labour18.07.01.0020.000049%Not Available
Presyncope02.11.04.013; 17.02.05.009; 24.06.02.0100.000049%
Proteinuria20.02.01.0110.000146%
Prothrombin level increased13.01.02.011--Not Available
Pruritus23.03.12.0010.001395%
Pruritus genital23.03.12.008; 21.10.01.002--Not Available
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Pulmonary oedema22.01.03.003; 02.05.02.003--
Pyrexia08.05.02.0030.000724%
Rash23.03.13.0010.002240%Not Available
Rash erythematous23.03.13.0290.000238%Not Available
Rash macular23.03.13.0030.000049%Not Available
Rash maculo-papular23.03.13.0040.000073%
Rash papular23.03.13.0170.000131%Not Available
Rash pruritic23.03.13.0300.000311%Not Available
Renal failure20.01.03.005--Not Available
Renal tubular necrosis20.01.07.0030.000049%Not Available
Respiratory distress22.02.01.0120.000049%Not Available
Retinal artery occlusion24.01.07.003; 06.10.01.0050.000049%Not Available
Rubber sensitivity23.03.04.036; 10.01.01.0250.000165%Not Available
Seizure17.12.03.001--
Serum sickness-like reaction08.01.03.003; 10.01.03.005--Not Available
Shock24.06.02.0020.000073%Not Available
Skin exfoliation23.03.07.0030.000073%Not Available
Skin reaction10.01.03.019; 23.03.03.013--Not Available
Sneezing22.12.03.0240.000049%
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