| Drug Name |
Chloroquine |
| Drug ID |
BADD_D00440 |
| Description |
Chloroquine is an aminoquinolone derivative first developed in the 1940s for the treatment of malaria.[A191655] It was the drug of choice to treat malaria until the development of newer antimalarials such as [pyrimethamine], [artemisinin], and [mefloquine].[A191787] Chloroquine and its derivative [hydroxychloroquine] have since been repurposed for the treatment of a number of other conditions including HIV, systemic lupus erythematosus, and rheumatoid arthritis.[A192432]
**The FDA emergency use authorization for [hydroxychloroquine] and chloroquine in the treatment of COVID-19 was revoked on 15 June 2020.[L14312]**
Chloroquine was granted FDA Approval on 31 October 1949.[L12054] |
| Indications and Usage |
Chloroquine is indicated to treat infections of _P. vivax_, _P. malariae_, _P. ovale_, and susceptible strains of _P. falciparum_.[L12051] It is also used to treat extraintestinal amebiasis.[L12051]
Chloroquine is also used off label for the treatment of rheumatic diseases,[A191655] as well as treatment and prophylaxis of Zika virus.[A191649,A191652] Chloroquine is currently undergoing clinical trials for the treatment of COVID-19.[A191631] |
| Marketing Status |
approved; investigational; vet_approved |
| ATC Code |
P01BA01 |
| DrugBank ID |
DB00608
|
| KEGG ID |
D02366
|
| MeSH ID |
D002738
|
| PubChem ID |
2719
|
| TTD Drug ID |
D09EGZ
|
| NDC Product Code |
Not Available |
| UNII |
886U3H6UFF
|
| Synonyms |
Chloroquine | Chlorochin | Chingamin | Khingamin | Nivaquine | Chloroquine Sulfate | Sulfate, Chloroquine | Chloroquine Sulphate | Sulphate, Chloroquine | Aralen | Arequin | Arechine |
