Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status approved; illicit
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 0781-8014; 82348-103; 69238-1305; 72205-047; 72606-003; 0832-0580; 10094-205; 10094-220; 69037-0009; 16729-446; 67877-658; 68180-156; 68180-158; 70710-1325; 70771-1441; 72205-048; 72606-004; 11014-0114; 42571-308; 48087-0117; 16714-888; 62135-527; 67386-315; 67877-665; 69452-116; 67877-666; 0832-0581; 51991-900; 59651-401; 69452-115; 10094-210; 31722-640; 42571-315; 51672-4202; 60687-423; 67386-314; 69238-1535; 69539-154; 65085-0054; 16714-887; 31722-639; 51672-4227; 66689-058; 11014-0115; 68180-157; 69238-1306; 69452-114; 70710-1326; 47621-047; 16729-445; 31722-641; 51672-4203; 0781-8013; 12828-0084; 69766-016; 16714-087; 51672-4210; 67386-313; 69539-153; 70771-1440; 48087-0094; 64330-110; 42571-316; 51991-901; 51991-958
UNII 2MRO291B4U
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Liver function test abnormal13.03.04.030--Not Available
Loss of libido19.08.03.003--Not Available
Lung disorder22.02.07.0010.000444%Not Available
Mental impairment17.03.03.002; 19.21.02.0030.000131%Not Available
Metabolic acidosis14.01.01.0030.000327%Not Available
Mood altered19.04.02.0070.005684%Not Available
Mouth ulceration07.05.06.0040.000131%Not Available
Muscle spasms15.05.03.004--
Muscle twitching15.05.03.0050.000797%Not Available
Muscular weakness15.05.06.001; 17.05.03.005--
Myalgia15.05.02.001--
Myoclonus17.02.05.0080.000196%Not Available
Nausea07.01.07.001--
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.003--Not Available
Nightmare19.02.03.003--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.001620%
Osteoarthritis15.01.04.001--Not Available
Pancreatitis07.18.01.0010.000196%
Paranoia19.05.01.0050.000287%Not Available
Personality disorder19.05.02.002--Not Available
Petit mal epilepsy17.12.04.0010.000261%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pregnancy18.08.02.0040.000640%Not Available
Pruritus23.03.12.001--
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.001333%Not Available
Psychomotor retardation19.15.02.0020.000131%Not Available
Pulmonary embolism24.01.06.001; 22.06.02.0010.000392%Not Available
Purpura24.07.06.005; 23.06.01.004; 01.01.04.0030.000131%
The 4th Page    First    Pre   4 5 6 7    Next   Last    Total 7 Pages
ADReCS-Target
Drug Name ADR Term Target
Tip:  Drug Name  ADR Term  Protein  Variation  Gene