Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clobazam
Drug ID BADD_D00488
Description Clobazam belongs to the 1,5-benzodiazepine class of drugs and is expected to have a better side-effect profile compared to older 1,4-benzodiazepines. It has been marketed as an anxiolytic since 1975 and an anticonvulsant since 1984. The oral preparation was FDA approved on October 21, 2011. An oral suspension is expected to be available in 2013.
Indications and Usage For treatment and management of epilepsy and seizures associated with Lennox-Gastaut syndrome, a difficult-to-treat form of childhood epilepsy.
Marketing Status approved; illicit
ATC Code N05BA09
DrugBank ID DB00349
KEGG ID D01253
MeSH ID D000078306
PubChem ID 2789
TTD Drug ID D0S9MC
NDC Product Code 0781-8014; 82348-103; 69238-1305; 72205-047; 72606-003; 0832-0580; 10094-205; 10094-220; 69037-0009; 16729-446; 67877-658; 68180-156; 68180-158; 70710-1325; 70771-1441; 72205-048; 72606-004; 11014-0114; 42571-308; 48087-0117; 16714-888; 62135-527; 67386-315; 67877-665; 69452-116; 67877-666; 0832-0581; 51991-900; 59651-401; 69452-115; 10094-210; 31722-640; 42571-315; 51672-4202; 60687-423; 67386-314; 69238-1535; 69539-154; 65085-0054; 16714-887; 31722-639; 51672-4227; 66689-058; 11014-0115; 68180-157; 69238-1306; 69452-114; 70710-1326; 47621-047; 16729-445; 31722-641; 51672-4203; 0781-8013; 12828-0084; 69766-016; 16714-087; 51672-4210; 67386-313; 69539-153; 70771-1440; 48087-0094; 64330-110; 42571-316; 51991-901; 51991-958
UNII 2MRO291B4U
Synonyms Clobazam | Urbanyl | Onfi | 1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine | HR 376 | LM-2717 | LM 2717 | LM2717 | Frisium
Chemical Information
Molecular Formula C16H13ClN2O2
CAS Registry Number 22316-47-8
SMILES CN1C(=O)CC(=O)N(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pyrexia08.05.02.0030.001633%
Rash23.03.13.0010.006037%Not Available
Rash erythematous23.03.13.0290.000131%Not Available
Respiratory arrest22.02.01.0090.000327%Not Available
Respiratory depression22.02.01.010; 17.02.05.0470.000457%Not Available
Respiratory disorder22.02.07.0020.000131%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Retching07.01.07.0020.000444%Not Available
Salivary hypersecretion07.06.01.0090.000444%Not Available
Sedation17.02.04.0050.008794%Not Available
Seizure17.12.03.0010.008676%
Skin disorder23.03.03.007--Not Available
Skin reaction23.03.03.013; 10.01.03.0190.000287%Not Available
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.0060.006847%
Speech disorder17.02.08.003; 22.12.03.027; 19.19.02.0020.000131%Not Available
Staring19.01.01.0030.000287%Not Available
Status epilepticus17.12.03.0050.001006%Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.0050.000261%
Suicidal ideation19.12.01.0030.000549%
Swelling face08.01.03.100; 23.04.01.018; 10.01.05.0180.000353%Not Available
Tension19.06.02.005--Not Available
Therapeutic response decreased08.06.01.0160.000392%Not Available
Thrombocytopenia01.08.01.002--Not Available
Tic19.11.04.001; 17.02.05.0240.000444%Not Available
Tonic convulsion17.12.03.0110.000131%Not Available
Toxic epidermal necrolysis12.03.01.015; 11.07.01.006; 10.01.01.006; 23.03.01.0080.000392%
Tremor17.01.06.002--
Unresponsive to stimuli17.02.05.0310.000196%Not Available
Upper respiratory tract infection22.07.03.011; 11.01.13.009--
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ADReCS-Target
Drug Name ADR Term Target
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