Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clomiphene citrate
Drug ID BADD_D00498
Description A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
Indications and Usage Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome) to induce ovulation.
Marketing Status approved; investigational
ATC Code G03GB02
DrugBank ID DB00882
KEGG ID D00962
MeSH ID D002996
PubChem ID 60974
TTD Drug ID D0I5WB
NDC Product Code 51927-0249; 73377-229; 49884-701; 50090-0678; 10577-916; 46014-1122; 51927-0056; 0713-0885; 73212-029; 63629-2165; 63629-5302; 63275-9964; 63629-9276; 48087-0025; 49169-1040; 51552-1580; 68071-2638; 73309-047; 50090-6500; 17369-817; 48087-0144; 62991-2702; 61919-375; 38779-0390; 43647-456; 71052-338; 90027-025
UNII 1B8447E7YI
Synonyms Clomiphene | Clomifene | Chloramiphene | Clomifen | Clomiphene Citrate | Citrate, Clomiphene | Clomiphene Hydrochloride | Hydrochloride, Clomiphene | Serophene | Gravosan | Klostilbegit | Clostilbegit | Clomid | Clomide | Dyneric
Chemical Information
Molecular Formula C32H36ClNO8
CAS Registry Number 50-41-9
SMILES CCN(CC)CCOC1=CC=C(C=C1)C(=C(C2=CC=CC=C2)Cl)C3=CC=CC=C3.C(C(=O)O)C(CC(=O)O)(C(=O) O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Weight increased13.15.01.006--
Breast discomfort21.05.05.007--Not Available
Transaminases increased13.03.04.036--Not Available
Neuroectodermal neoplasm17.20.01.006; 16.30.01.006--Not Available
Ear, nose and throat examination abnormal13.15.01.020--Not Available
Benign anorectal neoplasm16.05.02.002; 07.20.01.004--Not Available
Psychotic disorder19.03.01.002--
Hepatoblastoma09.04.02.003; 16.07.04.001--Not Available
Retinal vascular thrombosis24.01.07.001; 06.10.01.004--Not Available
Congenital foot malformation15.11.07.002; 03.11.07.002--Not Available
Congenital hand malformation15.11.07.005; 03.11.07.005--Not Available
Congenital jaw malformation15.11.05.003; 03.11.05.003--Not Available
Congenital joint malformation03.11.06.004; 15.11.06.004--Not Available
Renal aplasia20.01.02.001; 03.06.01.002--Not Available
Chronic kidney disease20.01.03.017--
Ovarian haemorrhage24.07.03.009; 21.11.02.006--
Dysmorphism15.11.06.001; 03.11.06.001--Not Available
Hepatic angiosarcoma24.03.06.007; 16.07.02.003; 09.04.02.007--Not Available
Cloacal exstrophy21.15.02.003; 20.08.03.004; 07.11.04.005; 03.03.02.004--Not Available
Renal cell carcinoma20.01.04.003; 16.08.02.002--Not Available
Intellectual disability19.21.06.001; 17.03.07.001--Not Available
Hepatocellular carcinoma16.07.02.005; 09.04.02.010--Not Available
Prolactin-producing pituitary tumour16.24.07.001; 05.03.05.005--Not Available
Abnormal uterine bleeding21.01.01.013--Not Available
Congenital musculoskeletal disorder03.11.06.010; 15.11.06.010--Not Available
Congenital musculoskeletal disorder of limbs15.11.07.028; 03.11.07.028--Not Available
Congenital musculoskeletal disorder of skull15.11.02.011; 03.11.02.011--Not Available
Congenital musculoskeletal disorder of spine15.11.04.007; 03.11.04.007--Not Available
Heavy menstrual bleeding21.01.03.005--Not Available
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