Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mutism19.19.01.001; 17.02.08.0070.007337%Not Available
Myalgia15.05.02.001--
Myasthenic syndrome16.32.01.002; 15.05.08.003; 10.04.05.005; 17.05.04.004--Not Available
Mydriasis17.02.11.003; 06.05.03.004--Not Available
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.0080.015286%Not Available
Myocarditis02.04.03.0010.230999%
Myoclonus17.02.05.0080.042556%Not Available
Nasal congestion22.04.04.001--
Nasal septum deviation22.04.03.0190.001223%Not Available
Nasopharyngitis11.01.13.002; 22.07.03.002--Not Available
Nausea07.01.07.001--
Negativism19.05.01.0120.003057%Not Available
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.0010.203607%Not Available
Neoplasm prostate16.25.02.001; 21.04.02.003--Not Available
Nephritis20.05.02.0010.001834%Not Available
Nervous system disorder17.02.10.001--Not Available
Neurogenic bladder20.03.03.001; 17.10.01.0020.001223%Not Available
Neuroleptic malignant syndrome15.05.04.015; 12.03.01.003; 08.05.01.005; 17.05.02.0030.070559%Not Available
Neurosis19.06.01.001--Not Available
Neutropenia01.02.03.0046.018703%Not Available
Neutrophilia01.02.01.0050.957382%Not Available
Nightmare19.02.03.003--Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.0010.018343%Not Available
Normochromic normocytic anaemia01.03.02.0050.002446%Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Obesity14.03.02.0090.026903%
Obsessive thoughts19.06.05.0010.001223%Not Available
Obsessive-compulsive disorder19.06.05.0020.015530%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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