Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Psychotic behaviour19.03.01.0030.007949%Not Available
Pulmonary embolism22.06.02.001; 24.01.06.001--Not Available
Pulmonary infarction24.04.09.001; 22.06.02.0020.001834%Not Available
Pulmonary valve incompetence02.07.04.0010.003669%Not Available
Pupillary reflex impaired06.05.03.009; 17.02.11.0070.002446%Not Available
Pyrexia08.05.02.003--
Rales22.12.01.0110.006114%Not Available
Rash23.03.13.001--Not Available
Rectal cancer16.13.01.003; 07.21.05.002--Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rectal prolapse07.03.01.0050.002446%Not Available
Renal failure20.01.03.005--Not Available
Repetitive speech19.19.02.003; 17.02.08.0120.002446%Not Available
Respiratory arrest22.02.01.009--Not Available
Respiratory depression17.02.05.047; 22.02.01.010--Not Available
Respiratory disorder22.02.07.0020.038765%Not Available
Respiratory distress22.02.01.012--Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.090492%
Restlessness19.11.02.002; 17.02.05.021--
Retrograde ejaculation21.03.01.0060.002446%Not Available
Rhabdomyolysis15.05.05.002--
Rhinorrhoea22.12.03.021--
Salivary gland enlargement07.06.03.002--Not Available
Salivary hypersecretion07.06.01.0090.174992%Not Available
Sarcoidosis10.02.06.001--Not Available
Sarcoma16.33.01.002; 15.09.03.0020.001834%Not Available
Schizoaffective disorder19.03.02.0020.059920%Not Available
Schizophrenia19.03.04.0010.859553%Not Available
Schizophreniform disorder19.03.02.001--Not Available
Screaming19.04.02.020; 08.01.03.0990.007582%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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