Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Uterine cancer21.07.02.003; 16.12.05.0010.004891%Not Available
Vasculitis24.12.04.027; 10.02.02.006--
Vein disorder24.03.02.0150.002446%Not Available
Venous thrombosis24.01.01.008--Not Available
Ventricular arrhythmia02.03.04.006--
Ventricular extrasystoles02.03.04.007--Not Available
Ventricular fibrillation02.03.04.008--
Ventricular hypertrophy02.04.02.0120.001223%Not Available
Ventricular tachycardia02.03.04.010--
Vertigo17.02.12.002; 04.04.01.003--
Vision blurred06.02.06.007; 17.17.01.010--
Visual impairment06.02.10.013--Not Available
Volvulus07.13.01.0120.009783%Not Available
Vomiting07.01.07.003--
Water intoxication05.03.03.003; 19.07.03.004; 14.05.06.0040.003669%Not Available
Waxy flexibility19.11.03.0050.002446%Not Available
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Wheezing22.03.01.009--
White blood cell count decreased13.01.06.012--
Mental status changes19.07.01.0010.091593%Not Available
Pneumoperitoneum07.07.01.0080.001223%Not Available
Tubulointerstitial nephritis20.05.02.002--Not Available
Mobility decreased15.03.05.023; 17.02.05.018; 08.01.03.0300.031428%Not Available
Cardiotoxicity12.03.01.007; 02.11.01.0090.017732%Not Available
Poor venous access24.03.02.0170.012840%Not Available
Underweight14.03.02.0170.001834%Not Available
Red blood cell sedimentation rate increased13.01.03.001--Not Available
Food aversion19.09.03.002; 14.03.02.0290.001834%Not Available
Sudden cardiac death08.04.01.008; 02.03.04.0160.004280%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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