Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
General physical health deterioration08.01.03.0180.166677%Not Available
Tachyarrhythmia02.03.02.008--Not Available
Homicidal ideation19.05.01.0080.009783%Not Available
Left ventricular dysfunction02.04.02.0110.028737%
Left ventricular hypertrophy02.04.02.0140.015286%Not Available
Cardiac death08.04.01.007; 02.03.04.0150.001223%Not Available
Idiosyncratic drug reaction08.06.01.0020.004525%Not Available
Abulia19.01.02.009; 17.02.05.040--Not Available
Lung cancer metastatic22.08.01.004; 16.19.02.0030.026292%Not Available
Pneumomediastinum22.09.03.0040.003669%Not Available
Subileus07.13.01.0040.006726%Not Available
Ventricular hypokinesia02.04.02.0130.011006%Not Available
Contusion15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001--
Hypochromasia01.07.02.0110.006114%Not Available
Floppy infant18.04.01.010; 17.05.02.012; 15.05.04.0140.001223%Not Available
Deep vein thrombosis24.01.02.003--Not Available
Cardiopulmonary failure22.02.06.004; 02.05.01.0040.004891%Not Available
Self-injurious ideation19.12.01.0070.010394%Not Available
Tonic clonic movements17.12.03.0060.003057%Not Available
Dyschezia07.02.03.0050.002446%Not Available
Exercise tolerance decreased08.01.03.036--Not Available
Systemic inflammatory response syndrome08.01.05.005; 24.06.03.008; 10.02.01.0080.007949%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Metabolic syndrome14.06.02.007; 05.06.02.007; 24.08.02.0140.011617%Not Available
Haemodynamic instability24.03.02.006--Not Available
Gastrointestinal hypomotility07.02.02.0050.016509%Not Available
Oesophageal rupture12.01.17.015; 07.04.05.0050.003669%Not Available
Lymphatic disorder01.09.01.003--Not Available
Diastolic dysfunction02.04.02.0220.004280%Not Available
Colorectal cancer metastatic16.13.01.005; 07.21.01.0050.002446%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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