Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Clozapine
Drug ID BADD_D00511
Description A tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also displays strong affinity to several dopaminergic receptors, but shows only weak antagonism at the dopamine D2 receptor, a receptor commonly thought to modulate neuroleptic activity. Agranulocytosis is a major adverse effect associated with administration of this agent.
Indications and Usage For use in patients with treatment-resistant schizophrenia.
Marketing Status approved
ATC Code N05AH02
DrugBank ID DB00363
KEGG ID D00283
MeSH ID D003024
PubChem ID 135398737
TTD Drug ID D0Z1RV
NDC Product Code 73377-150; 51079-288; 51079-749; 51407-085; 63629-2359; 0378-3813; 65862-846; 63552-062; 64374-004; 76072-1010; 16729-142; 57664-345; 0378-0973; 53296-0033; 0093-5416; 51079-921; 51079-922; 57664-211; 65862-845; 69809-0127; 55154-3568; 0378-0825; 0378-0860; 12828-0072; 51407-086; 63629-2360; 69809-0126; 67835-0028; 51862-900; 57664-241; 69809-0135; 70518-3391; 0093-5376; 0093-5417; 51862-902; 60687-404; 60687-415; 63629-2362; 0378-3815; 0904-7088; 65015-706; 0093-5419; 51862-901; 60687-426; 0378-0972; 65862-844; 70518-3357; 65862-847; 0904-7089; 63552-063; 16729-141; 0093-5377; 52817-601; 57664-347; 60687-548; 63629-2361; 69809-0130; 0904-7087; 71554-025; 51862-903
UNII J60AR2IKIC
Synonyms Clozapine | Clozaril | Leponex
Chemical Information
Molecular Formula C18H19ClN4
CAS Registry Number 5786-21-0
SMILES CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Right ventricular hypertrophy02.04.02.0340.001223%Not Available
Portal hypertensive gastropathy07.12.01.007; 24.08.06.006; 09.01.06.0220.001223%Not Available
Pulmonary cavitation22.01.02.0220.001834%Not Available
Adrenal mass05.01.03.003--Not Available
Progressive multiple sclerosis17.16.01.0060.001223%Not Available
Neurodegenerative disorder17.02.10.0240.005503%Not Available
Oesophageal cancer metastatic16.13.06.003; 07.21.06.0030.001223%Not Available
Breast cancer metastatic21.05.01.016; 16.10.01.0080.014063%Not Available
Colon cancer metastatic16.13.01.012; 07.21.01.0100.003057%Not Available
Autoimmune neutropenia10.04.01.010; 01.02.03.0130.001223%Not Available
Eosinophilic colitis07.08.01.019; 01.02.04.0150.002446%Not Available
Bifascicular block02.03.01.0200.001223%Not Available
Aortic dilatation24.03.04.0070.001223%Not Available
Ovarian cancer metastatic21.11.01.013; 16.12.04.0040.001834%Not Available
Multi-organ disorder08.01.03.0740.001223%Not Available
Neurogenic shock24.06.02.023; 17.02.10.025--Not Available
Parakeratosis23.03.03.0670.001834%Not Available
Sopor17.02.04.021; 19.02.04.0020.045246%Not Available
Abdominal compartment syndrome24.04.09.009; 07.11.01.0170.002446%Not Available
Psychogenic seizure17.12.03.042; 19.24.01.0070.003057%Not Available
Small cell lung cancer metastatic22.08.01.012; 16.19.08.0020.001834%Not Available
Diabetic foot24.04.03.015; 23.07.03.008; 17.09.04.006; 14.07.06.001; 05.07.06.0010.003057%Not Available
Appendix disorder07.11.01.0200.001223%Not Available
Communication disorder19.19.01.0080.007826%Not Available
Disturbance in social behaviour19.05.01.0180.007949%Not Available
Hernia obstructive08.01.04.0030.001223%Not Available
Psychotic disorder due to a general medical condition19.03.01.0080.001223%Not Available
Rectal neoplasm16.13.02.002; 07.21.10.0020.001223%Not Available
Spinal cord neoplasm16.30.01.009; 17.20.01.0090.001223%Not Available
Leukaemia recurrent16.01.03.005; 01.10.03.005--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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