Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Codeine
Drug ID BADD_D00516
Description The relief of pain (analgesia) is a primary goal for enhancing the quality of life of patients and for increasing the ability of patients to engage in day to day activities. Codeine, an opioid analgesic, was originally approved in the US in 1950 and is a drug used to decrease pain by increasing the threshold for pain without impairing consciousness or altering other sensory functions. Opiates such as codeine are derived from the poppy plant, _Papaver somniferum_ (Papaveraceae).[A175096] Codeine is utilized as a central analgesic, sedative, hypnotic, antinociceptive, and antiperistaltic agent, and is also recommended in certain diseases with incessant coughing.[LABEL,A175096]
Indications and Usage Codeine sulfate is a form of this drug that is commonly used. It is available in tablet form [FDA label] and indicated for the relief of mild to moderately severe pain, where the use of an opioid analgesic is appropriate [FDA label]. The solution form is used by itself or combined in a syrup with other drugs and is used as a cough suppressant in adults aged 18 and above [L5521], [L5524].
Marketing Status approved; illicit
ATC Code R05DA04
DrugBank ID DB00318
KEGG ID D00195; D02101
MeSH ID D003061
PubChem ID 5284371
TTD Drug ID D03DIG
NDC Product Code 10191-1035; 10191-1038; 10191-1033; 10191-1036; 10191-1034; 10191-1037
UNII Q830PW7520
Synonyms Codeine | Morphinan-6-ol, 7,8-didehydro-4,5-epoxy-3-methoxy-17-methyl-, (5alpha,6alpha)- | N-Methylmorphine | N Methylmorphine | Isocodeine | Codeine Phosphate | Ardinex
Chemical Information
Molecular Formula C18H21NO3
CAS Registry Number 76-57-3
SMILES CN1CCC23C4C1CC5=C2C(=C(C=C5)OC)OC3C(C=C4)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Affect lability19.04.01.001--Not Available
Injection site discomfort12.07.03.019; 08.02.03.0180.000343%Not Available
Metabolic disorder14.11.01.0010.000515%Not Available
Breast disorder21.05.04.004--Not Available
Cardiac disorder02.11.01.003--Not Available
Mediastinal disorder22.09.03.001--Not Available
Amnestic disorder19.20.05.001; 17.03.02.0070.000686%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Central nervous system stimulation25.04.01.001--Not Available
Renal neoplasm20.01.04.004; 16.08.03.0010.000343%Not Available
Ill-defined disorder08.01.03.049--Not Available
Pulmonary function test decreased13.19.01.001--Not Available
Bowel movement irregularity07.02.03.0030.000343%Not Available
Hypophagia19.09.01.004; 14.03.01.006; 07.01.06.0100.000343%Not Available
Cardiovascular insufficiency24.06.03.005; 02.11.01.011--Not Available
Sphincter of Oddi dysfunction09.02.02.004; 07.18.02.0020.000686%Not Available
Liver injury12.01.17.012; 09.01.07.0220.000686%Not Available
Low birth weight baby18.04.02.0030.000343%Not Available
Hypertransaminasaemia09.01.02.0050.000515%Not Available
Posterior reversible encephalopathy syndrome17.13.02.0070.000343%
Drug reaction with eosinophilia and systemic symptoms12.03.01.064; 23.03.05.005; 10.01.01.0210.000686%Not Available
Axillary mass15.03.02.0140.000343%Not Available
Live birth18.08.02.0070.000343%Not Available
Acute chest syndrome24.03.08.006; 22.06.03.004; 01.04.02.0040.000515%Not Available
Visceral congestion24.03.02.0330.000343%Not Available
Hyporesponsive to stimuli17.02.05.0570.000343%Not Available
Spinal pain17.10.01.020; 15.02.01.008; 08.01.08.0300.000343%Not Available
Behaviour disorder19.01.01.0050.000515%Not Available
Drug use disorder19.07.06.0120.001613%Not Available
Gastric stenosis07.13.04.0030.000343%
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ADReCS-Target
Drug Name ADR Term Target
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