Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cyproterone acetate
Drug ID BADD_D00555
Description An anti-androgen that, in the form of its acetate (cyproterone acetate), also has progestational properties. It is used in the treatment of hypersexuality in males, as a palliative in prostatic carcinoma, and, in combination with estrogen, for the therapy of severe acne and hirsutism in females.
Indications and Usage For the palliative treatment of patients with advanced prostatic carcinoma.
Marketing Status approved; investigational
ATC Code Not Available
DrugBank ID DB04839
KEGG ID D01368
MeSH ID D017373
PubChem ID 9880
TTD Drug ID Not Available
NDC Product Code 53104-7635; 46439-8720; 59010-000
UNII 4KM2BN5JHF
Synonyms Cyproterone Acetate | Cyproterone Acetate, (17 alpha)-Isomer | Cyproterone Acetate, (1 alpha,2 alpha,9 beta,10 alpha)-Isomer | Androcur | Cyproterone Acetate, (1 alpha,2 alpha)-Isomer
Chemical Information
Molecular Formula C24H29ClO4
CAS Registry Number 427-51-0
SMILES CC(=O)C1(CCC2C1(CCC3C2C=C(C4=CC(=O)C5CC5C34C)Cl)C)OC(=O)C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Muscular weakness17.05.03.005; 15.05.06.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Nausea07.01.07.001--
Neoplasm16.16.02.001--Not Available
Nitrogen balance negative13.13.01.010--Not Available
Normochromic normocytic anaemia01.03.02.005--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Optic atrophy06.09.02.001--Not Available
Optic neuritis06.04.08.002; 10.02.01.097; 17.04.05.001--Not Available
Osteoporosis15.02.03.002; 14.04.04.002--
Pancreatitis07.18.01.001--
Personality disorder19.05.02.002--Not Available
Phlebitis24.12.03.004; 12.02.01.002--
Photosensitivity reaction23.03.09.003--
Pollakiuria20.02.02.007--
Pruritus23.03.12.001--
Pulmonary embolism24.01.06.001; 22.06.02.001--Not Available
Pulmonary fibrosis22.01.02.006--
Rash23.03.13.001--Not Available
Rash maculo-papular23.03.13.004--
Renal failure20.01.03.005--Not Available
Retinal disorder06.08.03.005--Not Available
Retinal vascular disorder24.03.07.002; 06.10.01.002--
Retinal vein thrombosis24.01.07.002; 06.10.01.003--Not Available
Scleroderma10.04.07.001; 23.03.02.005; 15.06.01.002--Not Available
Shock24.06.02.002--Not Available
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin striae23.01.05.002--Not Available
Sleep disorder19.02.04.001--Not Available
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