Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dacarbazine
Drug ID BADD_D00568
Description An antineoplastic agent. It has significant activity against melanomas. (from Martindale, The Extra Pharmacopoeia, 31st ed, p564). Dacarbazine with Oblimersen is in clinical trials for the treatment of malignant melanoma.
Indications and Usage For the treatment of metastatic malignant melanoma. In addition, dacarbazine is also indicated for Hodgkin's disease as a secondary-line therapy when used in combination with other antineoplastic agents.
Marketing Status approved; investigational
ATC Code L01AX04
DrugBank ID DB00851
KEGG ID D00288
MeSH ID D003606
PubChem ID 2942
TTD Drug ID D0Y7ZU
NDC Product Code 42973-149; 63323-128; 0143-9245; 0703-5075; 54875-0003; 63323-127
UNII 7GR28W0FJI
Synonyms Dacarbazine | Dimethyl Imidazole Carboxamide | Carboxamide, Dimethyl Imidazole | Imidazole Carboxamide, Dimethyl | DTIC | ICDT | Decarbazine | 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide | DIC | Dimethyl Triazeno Imidazole Carboxamide | NSC-45388 | NSC 45388 | NSC45388 | DTIC-Dome | DTIC Dome | DTICDome | Biocarbazine | Deticene
Chemical Information
Molecular Formula C6H10N6O
CAS Registry Number 4342-03-4
SMILES CN(C)N=NC1=C(NC=N1)C(=O)N
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature menopause21.02.02.004; 05.05.01.0160.000112%
Proteinuria20.02.01.0110.000112%
Pyrexia08.05.02.0030.000280%
Rash23.03.13.0010.000112%Not Available
Rash erythematous23.03.13.029--Not Available
Rash maculo-papular23.03.13.0040.000112%
Seizure17.12.03.001--
Stomatitis07.05.06.005--
Tachycardia02.03.02.0070.000280%Not Available
Thrombocytopenia01.08.01.0020.000302%Not Available
Thrombotic microangiopathy24.01.01.013; 20.01.07.004; 01.01.02.0060.000168%Not Available
Urticaria10.01.06.001; 23.04.02.001--
Venoocclusive liver disease12.02.09.039; 24.04.07.002; 09.01.06.002--
Vision blurred17.17.01.010; 06.02.06.007--
Vomiting07.01.07.0030.000224%
Malignant neoplasm progression16.16.01.0050.000336%Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Vascular occlusion24.04.02.015--Not Available
Hepatic vein occlusion24.04.07.005; 09.01.06.011--Not Available
Hepatic enzyme increased13.03.04.028--Not Available
Neoplasm progression16.16.02.0050.000168%Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Renal function test abnormal13.13.01.012--Not Available
Ill-defined disorder08.01.03.049--Not Available
Disease progression08.01.03.0380.000168%
Venoocclusive disease24.03.02.016--Not Available
Renal impairment20.01.03.0100.000112%Not Available
Bone marrow failure01.03.03.005--
Acute kidney injury20.01.03.0160.000112%
Foetal growth restriction18.03.01.0020.000112%
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ADReCS-Target
Drug Name ADR Term Target
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