Adverse Drug Reaction Classification System

ADR Ontology
ADR Term Venoocclusive liver disease
ADR ID BADD_A04550
ADR Hierarchy
09      Hepatobiliary disorders
09.01      Hepatic and hepatobiliary disorders
09.01.06      Hepatic vascular disorders
09.01.06.002      Venoocclusive liver disease
24      Vascular disorders
24.04      Arteriosclerosis, stenosis, vascular insufficiency and necrosis
24.04.07      Hepatic and portal necrosis and vascular insufficiency
24.04.07.002      Venoocclusive liver disease
12      Injury, poisoning and procedural complications
12.02      Procedural related injuries and complications NEC
12.02.09      Transplantation complications
12.02.09.039      Venoocclusive liver disease
Description A condition in which the hepatic venous outflow is obstructed anywhere from the small HEPATIC VEINS to the junction of the INFERIOR VENA CAVA and the RIGHT ATRIUM. Usually the blockage is extrahepatic and caused by blood clots (THROMBUS) or fibrous webs. Parenchymal FIBROSIS is uncommon. [MeSH]
MedDRA Code 10047216
MeSH ID D006502; D006504
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE)
Synonym
Hepatic venous outflow obstruction | Veno-occlusive liver damage | Venoocclusive liver disease | Venoocclusive syndrome of the liver | Sinusoidal obstruction syndrome | Hepatic sinusoidal obstruction syndrome | Budd-Chiari Syndrome | Budd Chiari Syndrome | Hepatic Venous Outflow Obstruction | Chiari's Syndrome | Chiari Syndrome | Chiaris Syndrome | Hepatic Vein Thrombosis | Hepatic Vein Thromboses | Thromboses, Hepatic Vein | Thrombosis, Hepatic Vein | Vein Thromboses, Hepatic | Vein Thrombosis, Hepatic
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00132Amphotericin b--
BADD_D00230Bendamustine0.000112%
BADD_D00284Bortezomib--
BADD_D00318Busulfan0.001959%
BADD_D00349Capecitabine0.000168%
BADD_D00376Caspofungin0.000224%
BADD_D00474Cisplatin0.000224%
BADD_D00549Cyclophosphamide--
BADD_D00560Cytarabine0.000336%
BADD_D00568Dacarbazine--
BADD_D00571Dactinomycin0.000504%
BADD_D00723Doxorubicin0.000336%
BADD_D00854Etoposide0.000112%
BADD_D00864Ezetimibe0.000094%
BADD_D00914Fludarabine0.000336%
BADD_D00931Fluorouracil0.000184%
BADD_D01009Gemcitabine--
BADD_D01010Gemcitabine hydrochloride--
BADD_D01133Ifosfamide--
BADD_D01376Melphalan0.000224%
BADD_D01377Melphalan hydrochloride--
BADD_D01392Mercaptopurine0.001561%
BADD_D01508Mycophenolic acid0.000951%
BADD_D01633Oxaliplatin0.001511%
BADD_D01831Prednisolone0.000087%
BADD_D02105Tacrolimus0.002376%
BADD_D02199Thioguanine--
BADD_D02203Thiotepa0.000224%
BADD_D02360Vincristine0.000224%
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