Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dinoprostone
Drug ID BADD_D00684
Description Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.
Indications and Usage For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.
Marketing Status approved
ATC Code G02AD02
DrugBank ID DB00917
KEGG ID D00079
MeSH ID D015232
PubChem ID 5280360
TTD Drug ID D06FEA
NDC Product Code 0009-0058; 55566-2800; 82231-104; 68245-0015; 40016-012; 12079-0485; 45542-1153; 0009-3359
UNII K7Q1JQR04M
Synonyms Dinoprostone | PGE2 alpha | alpha, PGE2 | Prostaglandin E2alpha | E2alpha, Prostaglandin | Prostaglandin E2 | E2, Prostaglandin | Prostaglandin E2 alpha | E2 alpha, Prostaglandin | alpha, Prostaglandin E2 | PGE2 | PGE2alpha | Prepidil Gel | Gel, Prepidil | Prostenon
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 363-24-6
SMILES CCCCCC(C=CC1C(CC(=O)C1CC=CCCCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood disorder01.05.01.004--Not Available
Vaginal oedema21.08.02.0100.000207%Not Available
Uterine hyperstimulation21.07.03.006; 18.07.02.0080.000500%Not Available
Anaphylactoid syndrome of pregnancy22.06.02.004; 18.02.02.006; 10.01.07.005; 01.01.02.010; 24.01.06.0040.000102%Not Available
Post procedural infection12.02.05.010; 11.01.08.019--Not Available
Low birth weight baby18.04.02.0030.000041%Not Available
Vulvovaginal burning sensation21.08.02.0070.000130%Not Available
Vulvovaginal pain21.08.02.0090.000138%
Vulvovaginal erythema23.03.06.017; 21.08.02.0110.000110%Not Available
Hypoxic-ischaemic encephalopathy17.13.02.006; 24.04.06.021; 22.02.02.0110.000061%Not Available
Vulvovaginal swelling21.08.02.0160.000455%Not Available
Foetal heart rate deceleration abnormality18.03.02.012; 02.03.02.0220.000211%Not Available
Genito-pelvic pain/penetration disorder21.03.02.022; 19.08.05.006--Not Available
Abnormal labour affecting foetus18.03.03.003--Not Available
Neonatal asphyxia22.11.02.006; 18.04.15.0050.000305%Not Available
Neonatal respiratory distress syndrome22.11.02.010; 18.04.10.003--Not Available
Transient tachypnoea of the newborn22.11.01.010; 18.04.09.0100.000041%Not Available
Meconium in amniotic fluid18.05.01.007--Not Available
Meconium stain18.05.01.0080.000041%Not Available
Nonreassuring foetal heart rate pattern18.03.02.017; 02.03.02.0270.000061%Not Available
Encephalopathy neonatal18.04.04.015; 17.13.02.014--Not Available
Therapeutic product effect incomplete08.06.01.052--Not Available
Uterine tachysystole21.07.03.007; 18.07.02.0130.000289%Not Available
Vulvovaginal inflammation21.14.02.014--Not Available
Labour pain18.08.02.009--Not Available
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ADReCS-Target
Drug Name ADR Term Target
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