Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Disulfiram
Drug ID BADD_D00695
Description A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase.
Indications and Usage For the treatment and management of chronic alcoholism
Marketing Status approved
ATC Code N07BB01; P03AA04
DrugBank ID DB00822
KEGG ID D00131
MeSH ID D004221
PubChem ID 3117
TTD Drug ID D0X5SD
NDC Product Code 42973-137; 71052-221; 42794-028; 0054-0357; 73309-150; 51927-3121; 62135-432; 64980-171; 0054-0356; 38779-1971; 65571-0005; 62135-431; 64980-172; 51927-0188; 72643-028; 47781-607; 60429-196
UNII TR3MLJ1UAI
Synonyms Disulfiram | Bis(diethylthiocarbamoyl) Disulfide | Tetraethylthioperoxydicarbonic Diamide, ((H2N)C(S))2S2 | Tetraethylthiuram Disulfide | Disulfide, Tetraethylthiuram | Antabus | Antabuse | Teturam | Dicupral | Esperal | Alcophobin | Anticol
Chemical Information
Molecular Formula C10H20N2S4
CAS Registry Number 97-77-8
SMILES CCN(CC)C(=S)SSC(=S)N(CC)CC
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hepatitis09.01.07.004--Not Available
Hepatitis fulminant11.07.01.003; 09.01.07.007--Not Available
Hepatitis toxic12.03.01.016; 09.01.07.0170.003777%Not Available
Hepatomegaly09.01.05.0010.005665%Not Available
Hypertension24.08.02.0010.009442%
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypomania19.16.02.0010.003777%Not Available
Hypotension24.06.03.0020.007553%
Insomnia17.15.03.002; 19.02.01.0020.007553%
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.0040.003777%Not Available
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.003777%
Metabolic acidosis14.01.01.0030.005665%Not Available
Methaemoglobinaemia01.05.01.0020.005665%
Neuritis17.09.03.001--Not Available
Neuropathy peripheral17.09.03.0030.037767%Not Available
Neurotoxicity12.03.01.011; 17.02.10.0020.007553%Not Available
Optic neuritis10.02.01.097; 17.04.05.001; 06.04.08.002--Not Available
Pain08.01.08.004--
Paraesthesia23.03.03.094; 17.02.06.005--
Peripheral sensory neuropathy17.09.03.0050.003777%
Peroneal nerve palsy17.09.02.0030.003777%Not Available
Polyneuropathy17.09.03.0120.011330%Not Available
Portal hypertension24.08.06.001; 09.01.06.0060.003777%
Rash23.03.13.001--Not Available
Seizure17.12.03.0010.003777%
Sensory loss17.02.07.007--Not Available
Somnolence19.02.05.003; 17.02.04.0060.003777%
Stress19.06.02.004--Not Available
Suicide attempt19.12.01.0040.005665%
Syncope17.02.04.008; 02.11.04.015; 24.06.02.0120.011330%
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ADReCS-Target
Drug Name ADR Term Target
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