Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Epoprostenol
Drug ID BADD_D00788
Description A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from prostaglandin endoperoxides in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension.
Indications and Usage For the long-term intravenous treatment of primary pulmonary hypertension and pulmonary hypertension associated with the scleroderma spectrum of disease in NYHA Class III and Class IV patients who do not respond adequately to conventional therapy.
Marketing Status approved
ATC Code B01AC09
DrugBank ID DB01240
KEGG ID D00106
MeSH ID D011464
PubChem ID 5282411
TTD Drug ID D0V0IX
NDC Product Code 66215-402; 62756-060; 66215-403; 62287-123; 62756-059
UNII DCR9Z582X0
Synonyms Epoprostenol | Epoprostanol | Prostaglandin I2 | Prostacyclin | Prostaglandin I(2) | Veletri | Epoprostenol Sodium | Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer | Flolan
Chemical Information
Molecular Formula C20H32O5
CAS Registry Number 35121-78-9
SMILES CCCCCC(C=CC1C(CC2C1CC(=CCCCC(=O)O)O2)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Premature labour18.07.01.0020.000082%Not Available
Presyncope17.02.05.009; 24.06.02.010; 02.11.04.0130.000428%
Proctalgia07.03.02.0010.000082%
Productive cough22.02.03.0050.000387%
Pruritus23.03.12.001--
Pulmonary embolism22.06.02.001; 24.01.06.001--Not Available
Pulmonary fibrosis22.01.02.0060.000164%
Pulmonary haemorrhage22.12.01.009; 24.07.01.0160.000288%
Pulmonary hypertension24.08.03.002; 22.06.01.0010.001826%
Pulmonary oedema02.05.02.003; 22.01.03.0030.000658%
Pulmonary thrombosis24.01.06.002; 22.06.02.0030.000123%Not Available
Pulmonary veno-occlusive disease24.01.06.008; 22.06.03.0030.000329%Not Available
Pyrexia08.05.02.0030.002558%
Rash23.03.13.0010.003199%Not Available
Rash erythematous23.03.13.0290.000543%Not Available
Rash macular23.03.13.0030.000206%Not Available
Rash papular23.03.13.0170.000263%Not Available
Rash pruritic23.03.13.0300.000387%Not Available
Raynaud's phenomenon24.04.03.0030.000082%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.001--
Rectal prolapse07.03.01.0050.000082%Not Available
Renal disorder20.01.02.0020.000370%Not Available
Renal failure20.01.03.0050.001069%Not Available
Respiratory arrest22.02.01.0090.000288%Not Available
Respiratory disorder22.02.07.0020.000164%Not Available
Respiratory distress22.02.01.0120.000576%Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000987%
Retching07.01.07.0020.000304%Not Available
Retroperitoneal haemorrhage12.01.17.018; 24.07.01.017; 07.07.02.0020.000082%
Rhinitis22.07.03.006; 11.01.13.004--
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