Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Exemestane
Drug ID BADD_D00861
Description Exemestane is an oral steroidal aromatase inhibitor used in the adjuvant treatment of hormonally-responsive (also called hormone-receptor-positive, estrogen-responsive) breast cancer in postmenopausal women. It irreversibly binds to the active site of the enzyme resulting in permanent inhibition.
Indications and Usage For the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Marketing Status approved; investigational
ATC Code L02BG06
DrugBank ID DB00990
KEGG ID D00963
MeSH ID C056516
PubChem ID 60198
TTD Drug ID D0D2VS
NDC Product Code 62157-091; 65129-1217; 44278-025; 71921-190; 51552-1619; 65427-030; 68724-1003; 51991-005; 63629-2056; 68382-383; 49386-026; 73377-132; 46439-8746; 59762-2858; 70771-1374; 65162-240; 0054-0080; 69097-316; 59057-007; 64918-0622; 64181-0005; 59651-516; 52128-134; 64918-0621; 53104-7666; 59057-008; 0832-0595; 65089-0046; 0009-7663
UNII NY22HMQ4BX
Synonyms exemestane | examestane | 6-methyleneandrosta-1,4-diene-3,17-dione | FCE 24304 | FCE-24304 | Aromasil | Aromasin | Aromasine
Chemical Information
Molecular Formula C20H24O2
CAS Registry Number 107868-30-4
SMILES CC12CCC3C(C1CCC2=O)CC(=C)C4=CC(=O)C=CC34C
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Metastatic malignant melanoma23.08.01.002; 16.03.01.0020.001568%Not Available
Migraine24.03.05.003; 17.14.02.0010.004078%Not Available
Monoplegia17.01.04.003--Not Available
Multiple fractures15.08.02.005; 12.04.02.009--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.0010.007424%
Musculoskeletal pain15.03.04.0070.004601%
Myalgia15.05.02.0010.018927%
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia02.02.02.008; 24.04.04.010--Not Available
Nasal congestion22.04.04.0010.004078%
Nausea07.01.07.001--
Neoplasm16.16.02.0010.003346%Not Available
Neoplasm malignant16.16.01.0010.015580%Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.005856%Not Available
Neuralgia17.02.07.0050.002300%
Neuropathy peripheral17.09.03.0030.003869%Not Available
Neutropenia01.02.03.0040.006274%Not Available
Night sweats23.02.03.006; 08.01.03.0310.003555%Not Available
Oedema14.05.06.010; 08.01.07.0060.003346%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.0070.004915%
Opportunistic infection11.01.08.007--Not Available
Optic neuritis10.02.01.097; 17.04.05.001; 06.04.08.0020.001046%Not Available
Osteoarthritis15.01.04.0010.001568%Not Available
Osteochondrosis15.07.03.002--Not Available
Osteonecrosis24.04.05.004; 15.02.04.0070.001046%
Osteoporosis15.02.03.002; 14.04.04.0020.003869%
Osteoporotic fracture15.08.02.007; 14.04.04.007; 12.04.02.005--Not Available
Ovarian cancer21.11.01.003; 16.12.04.0010.002091%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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