Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Fomepizole
Drug ID BADD_D00956
Description Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Indications and Usage Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
Marketing Status approved; vet_approved
ATC Code V03AB34
DrugBank ID DB01213
KEGG ID D00707
MeSH ID D000077604
PubChem ID 3406
TTD Drug ID D02NJA
NDC Product Code 0517-0710; 50384-0600; 70710-1478; 65732-702; 14096-107; 17511-101; 67457-211; 68083-510; 76339-106; 68475-510
UNII 83LCM6L2BY
Synonyms Fomepizole | 4-Methylpyrazole | 4 Methylpyrazole | Antizol | 4-Methylpyrazole Monohydrochloride | 4 Methylpyrazole Monohydrochloride
Chemical Information
Molecular Formula C4H6N2
CAS Registry Number 7554-65-6
SMILES CC1=CNN=C1
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Agitation19.06.02.001; 17.02.05.012--
Anaemia01.03.02.001--
Anuria20.01.03.002--Not Available
Anxiety19.06.02.002--
Application site reaction12.07.01.006; 08.02.01.006--Not Available
Back pain15.03.04.005--
Body temperature increased13.15.01.001--Not Available
Bradycardia02.03.02.002--Not Available
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Disseminated intravascular coagulation24.01.01.010; 01.01.02.002--
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dysgeusia07.14.03.001; 17.02.07.003--
Dyspepsia07.01.02.001--
Eosinophilia01.02.04.001--
Feeling abnormal08.01.09.014--Not Available
Feeling drunk08.01.09.015--Not Available
Flushing08.01.03.025; 23.06.05.003; 24.03.01.002--
Gastrointestinal pain07.01.05.005--
Hangover08.01.09.018--Not Available
Headache17.14.01.001--
Hiccups22.12.01.001; 07.01.06.009--
Hypotension24.06.03.002--
Injection site inflammation08.02.03.008; 12.07.03.009--Not Available
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Lymphangitis24.09.02.001; 11.01.15.001; 01.09.01.005--Not Available
Nausea07.01.07.001--
Nystagmus17.02.02.006; 06.05.02.006--
Pain08.01.08.004--
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ADReCS-Target
Drug Name ADR Term Target
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