Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Gatifloxacin
Drug ID BADD_D01006
Description Gatifloxacin is an antibiotic agent and a member of the fourth-generation fluoroquinolone family. It works by inhibiting the bacterial enzymes DNA gyrase and topoisomerase IV. It was first introduced by Bristol-Myers Squibb in 1999 under the brand name Tequin® for the treatment of respiratory tract infections. Gatifloxacin is available as tablets and in various aqueous solutions for intravenous therapy. It is also available as eye drops under the brand name Zymar® marketed by Allergan.
Indications and Usage For the treatment of bronchitis, sinusitis, community-acquired pneumonia, and skin infections (abscesses, wounds) caused by S. pneumoniae, H. influenzae, S. aureus, M. pneumoniae, C. pneumoniae, L. pneumophila, S. pyogenes
Marketing Status approved; investigational
ATC Code J01MA16; S01AE06
DrugBank ID DB01044
KEGG ID D00589; D08011
MeSH ID D000077734
PubChem ID 5379
TTD Drug ID D03CQE
NDC Product Code 53476-1155; 50383-189; 68180-435; 60758-615; 61314-672; 0023-3615
UNII L4618BD7KJ
Synonyms Gatifloxacin | 1-cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid | Gatifloxacine | Tequin | AM 1155 | AM-1155 | CG 5501 | BMS-206584 | BMS 206584 | BMS206584 | Zymar
Chemical Information
Molecular Formula C19H22FN3O4
CAS Registry Number 112811-59-3
SMILES CC1CN(CCN1)C2=C(C=C3C(=C2OC)N(C=C(C3=O)C(=O)O)C4CC4)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypoglycaemia14.06.03.001; 05.06.03.001--
Hypoglycaemic coma17.02.09.005; 14.06.03.004; 05.06.03.004--Not Available
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Injection site reaction12.07.03.015; 08.02.03.014--
Insomnia17.15.03.002; 19.02.01.002--
Instillation site pain12.07.01.008; 08.02.01.0080.001437%Not Available
Iritis10.02.01.022; 06.04.03.002--Not Available
Keratitis06.04.02.002--
Lacrimation increased06.08.02.004--
Loss of consciousness17.02.04.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Macular oedema06.04.06.005--Not Available
Mental disability26.01.01.001--Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.001--
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Nervousness19.06.02.003--Not Available
Neutropenia01.02.03.004--Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema mouth23.04.01.008; 10.01.05.006; 07.05.04.001--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Palpitations02.11.04.012--
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ADReCS-Target
Drug Name ADR Term Target
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