| Pharmaceutical Information |
| Drug Name |
Glucagon hydrochloride |
| Drug ID |
BADD_D01026 |
| Description |
Glucagon is a 29 amino acid hormone used as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] Glucagon raises blood sugar through activation of hepatic glucagon receptors, stimulating glycogenolysis and the release of glucose.[L7640,L7643]
Glucagon was granted FDA approval on 14 November 1960.[L7631] |
| Indications and Usage |
Glucagon is indicated as a diagnostic aid in radiologic exams to temporarily inhibit the movement of the gastrointestinal tract and to treat severe hypoglycemia.[L7634,L7637,L7640,L7643,L8519] |
| Marketing Status |
approved |
| ATC Code |
H04AA01 |
| DrugBank ID |
DB00040
|
| KEGG ID |
D02118
|
| MeSH ID |
D005934
|
| PubChem ID |
16186213
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
0169-7065; 0597-0053; 0597-0260 |
| UNII |
1H87NVF4DB
|
| Synonyms |
Glucagon | Proglucagon (33-61) | HG-Factor | HG Factor | Glukagon | Glucagon (1-29) | Hyperglycemic-Glycogenolytic Factor | Hyperglycemic Glycogenolytic Factor |
|
| Chemical Information |
| Molecular Formula |
C153H226ClN43O49S |
| CAS Registry Number |
19179-82-9 |
| SMILES |
CC(C)CC(C(=O)NC(CCSC)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)O)NC(=O)C(CC1=CNC2=CC=CC
=C21)NC(=O)C(CCC(=O)N)NC(=O)C(C(C)C)NC(=O)C(CC3=CC=CC=C3)NC(=O)C(CC(=O)O)NC(=O)C
(CCC(=O)N)NC(=O)C(C)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CO)NC(=O)C(CC(
=O)O)NC(=O)C(CC(C)C)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CCCCN)NC(=O)C(CO)NC(=O)C(CC5
=CC=C(C=C5)O)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C(CC6=CC=CC=C6)NC(=O
)C(C(C)O)NC(=O)CNC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CC7=CN=CN7)N.Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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|
| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
|
ADR Severity Grade (FAERS)
|
ADR Severity Grade (CTCAE)
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| Hypoglycaemia | 14.06.03.001; 05.06.03.001 | - | - | | | Hypoglycaemic coma | 14.06.03.004; 05.06.03.004; 17.02.09.005 | - | - | Not Available | | Nausea | 07.01.07.001 | - | - | | | Vomiting | 07.01.07.003 | - | - | |
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