| Pharmaceutical Information |
| Drug Name |
Halofantrine hydrochloride |
| Drug ID |
BADD_D01053 |
| Description |
Halofantrine is an antimalarial. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity. |
| Indications and Usage |
For treatment of Severe malaria |
| Marketing Status |
approved |
| ATC Code |
P01BX01 |
| DrugBank ID |
DB01218
|
| KEGG ID |
D02485
|
| MeSH ID |
C023768
|
| PubChem ID |
37392
|
| TTD Drug ID |
D07MVK
|
| NDC Product Code |
52286-4195 |
| UNII |
H77DL0Y630
|
| Synonyms |
halofantrine | halofantrine hydrochloride | 1-(1,3-dichloro-6-trifluoromethyl-9-phenanthryl)-3-di(n-butyl)aminopropanol HCl | WR 171,699 | WR-171,669 | WR-171699 | WR 171669 | Halfan |
|
| Chemical Information |
| Molecular Formula |
C26H31Cl3F3NO |
| CAS Registry Number |
36167-63-2 |
| SMILES |
CCCCN(CCCC)CCC(C1=C2C=CC(=CC2=C3C=C(C=C(C3=C1)Cl)Cl)C(F)(F)F)O.Cl |
| Chemical Structure |
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| ADRs Induced by Drug |
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