Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Laronidase
Drug ID BADD_D01249
Description Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites.
Indications and Usage For the treatment of mucopolysaccharidosis
Marketing Status approved
ATC Code A16AB05
DrugBank ID DB00090
KEGG ID D04670
MeSH ID Not Available
PubChem ID Not Available
TTD Drug ID D03LUN
NDC Product Code 68135-000; 58468-0070
UNII WP58SVM6R4
Synonyms Not Available
Chemical Information
Molecular Formula Not Available
CAS Registry Number 210589-09-6
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abscess11.01.08.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Arthralgia15.01.02.001--
Back pain15.03.04.005--
Blood pressure increased13.14.03.005--Not Available
Cardiac failure02.05.01.001--
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Chest pain02.02.02.011; 22.12.02.003; 08.01.08.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Corneal opacity06.06.03.005--Not Available
Crepitations08.01.03.006--Not Available
Cyanosis24.03.01.007; 22.02.02.007; 23.06.04.005; 02.11.04.004--
Death08.04.01.001--
Diarrhoea07.02.01.001--
Erythema23.03.06.001--Not Available
Extravasation08.01.03.008--Not Available
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Feeling cold08.01.09.008--Not Available
Feeling hot08.01.09.009--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gravitational oedema08.01.07.005; 02.05.04.014--Not Available
Headache17.14.01.001--
Hyperbilirubinaemia01.06.04.003; 14.11.01.010; 09.01.01.003--Not Available
Hyperreflexia17.02.01.002--Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
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