Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lincomycin hydrochloride
Drug ID BADD_D01293
Description Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska.[A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains in use.[A190657, A190621] Lincomycin was approved by the FDA on December 29, 1964.[L33214]
Indications and Usage Lincomycin is indicated for the treatment of serious bacterial infections by susceptible strains of streptococci, pneumococci, and staphylococci in patients who are allergic to penicillins or for situations in which a penicillin is deemed inappropriate. As with all antibacterial agents, lincomycin should only be used to treat infections proven or strongly suspected to be caused by susceptible bacteria.[L33214]
Marketing Status approved; vet_approved
ATC Code J01FF02
DrugBank ID DB01627
KEGG ID D02346; D00223
MeSH ID D008034
PubChem ID 64710
TTD Drug ID D0Q0EX
NDC Product Code 39822-0353; 51927-3177; 50090-4533; 43781-2301; 52584-353; 0404-9901; 42881-0001; 39822-0350; 68083-478; 0009-5168; 0009-0555; 20076-0404; 68083-479; 25021-193
UNII M6T05Z2B68
Synonyms Lincomycin | Lincomycin A | Lincolnensin | Lincomycin Hydrochloride | Lincomycin Monohydrochloride | Lincomycin, (L-threo)-Isomer | Epilincomycin | Lincomycin Monohydrochloride, (L-threo)-Isomer | Lincomycin Monohydrochloride, Hemihydrate | Hemihydrate Lincomycin Monohydrochloride | Lincomycin, (2S-cis)-Isomer | Lincocin | Lincomycin Monohydrochloride, (2S-cis)-Isomer
Chemical Information
Molecular Formula C18H35ClN2O6S
CAS Registry Number 859-18-7
SMILES CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abscess11.01.08.001--Not Available
Agranulocytosis01.02.03.001--Not Available
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angioedema23.04.01.001; 10.01.05.009; 22.04.02.008--Not Available
Aplastic anaemia01.03.03.002--Not Available
Azotaemia20.01.01.001--Not Available
Blepharitis23.03.04.012; 06.04.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Clostridium difficile colitis07.19.01.004; 11.02.02.004--Not Available
Colitis07.08.01.001--
Cyanosis22.02.02.007; 23.06.04.005; 02.11.04.004; 24.03.01.007--
Dermatitis23.03.04.002--Not Available
Dermatitis bullous23.03.01.002--
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Enterocolitis07.08.03.003--
Erythema23.03.06.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Faeces discoloured07.01.03.002--Not Available
Glossitis07.14.01.001--Not Available
Hepatic function abnormal09.01.02.001--Not Available
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Injection site abscess sterile12.07.03.040; 08.02.03.040--Not Available
Injection site induration08.02.03.007; 12.07.03.007--Not Available
Injection site irritation12.07.03.027; 08.02.03.027--Not Available
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