Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lincomycin hydrochloride
Drug ID BADD_D01293
Description Lincomycin is a lincosamide antibiotic first isolated from the soil bacterium _Streptomyces lincolnensis_ in Lincoln, Nebraska.[A190621] Clinical use of lincomycin has largely been superseded by its semisynthetic derivative [clindamycin] due to its higher efficacy and a wider range of susceptible organisms, though lincomycin remains in use.[A190657, A190621] Lincomycin was approved by the FDA on December 29, 1964.[L33214]
Indications and Usage Lincomycin is indicated for the treatment of serious bacterial infections by susceptible strains of streptococci, pneumococci, and staphylococci in patients who are allergic to penicillins or for situations in which a penicillin is deemed inappropriate. As with all antibacterial agents, lincomycin should only be used to treat infections proven or strongly suspected to be caused by susceptible bacteria.[L33214]
Marketing Status approved; vet_approved
ATC Code J01FF02
DrugBank ID DB01627
KEGG ID D02346; D00223
MeSH ID D008034
PubChem ID 64710
TTD Drug ID D0Q0EX
NDC Product Code 39822-0353; 51927-3177; 50090-4533; 43781-2301; 52584-353; 0404-9901; 42881-0001; 39822-0350; 68083-478; 0009-5168; 0009-0555; 20076-0404; 68083-479; 25021-193
UNII M6T05Z2B68
Synonyms Lincomycin | Lincomycin A | Lincolnensin | Lincomycin Hydrochloride | Lincomycin Monohydrochloride | Lincomycin, (L-threo)-Isomer | Epilincomycin | Lincomycin Monohydrochloride, (L-threo)-Isomer | Lincomycin Monohydrochloride, Hemihydrate | Hemihydrate Lincomycin Monohydrochloride | Lincomycin, (2S-cis)-Isomer | Lincocin | Lincomycin Monohydrochloride, (2S-cis)-Isomer
Chemical Information
Molecular Formula C18H35ClN2O6S
CAS Registry Number 859-18-7
SMILES CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)O.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Injection site pain12.07.03.011; 08.02.03.010--Not Available
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Leukocytosis01.02.01.002--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Local reaction08.01.03.012--Not Available
Megacolon07.02.05.002--Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oesophagitis07.08.05.001--
Oliguria20.01.03.004--Not Available
Pain08.01.08.004--
Pancytopenia01.03.03.003--Not Available
Peritonitis11.01.07.007; 07.19.05.004--
Phlebitis24.12.03.004; 12.02.01.002--
Photosensitivity reaction23.03.09.003--
Proteinuria20.02.01.011--
Pruritus23.03.12.001--
Pruritus genital23.03.12.008; 21.10.01.002--Not Available
Pseudomembranous colitis11.02.02.002; 07.19.01.003--Not Available
Rash23.03.13.001--Not Available
Rash erythematous23.03.13.029--Not Available
Rash macular23.03.13.003--Not Available
Rash maculo-papular23.03.13.004--
Rash pustular23.03.10.003; 11.01.12.002--
Serum sickness12.02.08.004; 10.01.03.004--
Shock24.06.02.002--Not Available
Stevens-Johnson syndrome10.01.01.045; 23.03.01.007; 12.03.01.014; 11.07.01.005--
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