Adverse Drug Reaction Classification System

         

ADR Ontology
ADR Term Megacolon
ADR ID BADD_A02693
ADR Hierarchy
07      Gastrointestinal disorders
07.02      Gastrointestinal motility and defaecation conditions
07.02.05      Non-mechanical ileus
07.02.05.002      Megacolon
Description Dilatation of the COLON, often to alarming dimensions. There are various types of megacolon including congenital megacolon in HIRSCHSPRUNG DISEASE, idiopathic megacolon in CONSTIPATION, and TOXIC MEGACOLON. [MeSH]
MedDRA Code 10027110
MeSH ID D008531
ADR Severity Grade (FAERS)
ADR Severity Grade (CTCAE) Not Available
Synonym
Acquired megacolon | Giant colon | Megacolon | Megacolon acquired | Megacolon aquired | Megacolon NOS | Megacolon toxic | Megacolon, other than Hirschsprung's | Toxic dilatation of colon | Colectasia | Megarectum | Megacolons
Drugs Leading to the ADR
Drug IDDrug NameADR Frequency (FAERS)ADR Severity Grade (FAERS)
BADD_D00284Bortezomib--
BADD_D00349Capecitabine0.000392%
BADD_D00445Chlorpromazine--
BADD_D00446Chlorpromazine hydrochloride--
BADD_D00471Ciprofloxacin--
BADD_D00480Clarithromycin0.000447%
BADD_D00511Clozapine0.015897%
BADD_D00560Cytarabine0.000168%
BADD_D00563Dabigatran0.000245%
BADD_D00623Dexamethasone0.000291%
BADD_D00688Diphenoxylate hydrochloride--
BADD_D00773Entacapone0.002744%
BADD_D00800Erlotinib0.000112%
BADD_D00871Felbamate--
BADD_D00896Fidaxomicin--
BADD_D00965Fosfomycin--
BADD_D00966Fosfomycin tromethamine--
BADD_D01013Gemifloxacin--
BADD_D01195Irinotecan--
BADD_D01196Irinotecan hydrochloride--
BADD_D01213Isotretinoin0.000386%
BADD_D01243Lamotrigine0.000055%
BADD_D01293Lincomycin hydrochloride--
BADD_D01314Loperamide cation--
BADD_D01315Loperamide hydrochloride--
BADD_D01418Methotrexate--
BADD_D01449Metronidazole0.000066%
BADD_D01498Morphine0.000111%
BADD_D01668Pantoprazole0.000016%
BADD_D01834Prednisone0.000009%
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