Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Loperamide hydrochloride
Drug ID BADD_D01315
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status approved
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D00729
MeSH ID D008139
PubChem ID 71420
TTD Drug ID D0CS2F
NDC Product Code 47682-200; 49035-520; 50268-482; 50580-317; 53943-176; 55315-123; 0363-1176; 67751-162; 68016-123; 70518-0313; 70677-1062; 72578-138; 72888-130; 73581-777; 41250-210; 42799-605; 51660-123; 63868-876; 68071-2700; 69842-061; 70518-0072; 71335-1921; 72288-758; 73581-102; 49452-4133; 30142-159; 30142-520; 36800-224; 49348-529; 50804-520; 55154-4699; 63629-1452; 0378-2100; 68071-2863; 68094-129; 68788-8393; 70000-0461; 71610-648; 80136-851; 59651-022; 66577-015; 11673-224; 0113-0224; 41250-224; 41250-520; 50090-6208; 50580-134; 59556-959; 63868-338; 63941-123; 68391-224; 70518-3400; 70677-0060; 70771-1769; 71205-079; 71335-2111; 17337-0052; 17337-0526; 38779-0446; 51079-690; 59779-700; 60687-229; 63187-462; 63868-748; 68788-8951; 68998-123; 70518-3413; 73581-101; 51927-0174; 46122-738; 61919-423; 63629-8747; 71335-2061; 10888-8117; 10888-8122; 48292-0029; 68981-022; 11673-177; 0093-0311; 43598-770; 53329-664; 53943-123; 55910-224; 58602-701; 60468-005; 62011-0390; 67296-1481; 69452-271; 71205-316; 0904-7725; 11822-7834; 36800-208; 43063-020; 50090-0460; 50580-367; 52904-443; 55289-315; 66715-9859; 67296-0346; 70518-0893; 0615-8087; 75907-097; 17337-0053; 51927-2357; 35418-123; 37808-988; 41520-520; 41520-841; 49035-483; 55910-176; 56062-224; 67296-1472; 68016-058; 68071-2257; 69452-176; 69452-266; 10888-8123; 12578-409; 49632-070; 24385-554; 33992-0820; 46122-581; 51655-663; 58602-870; 59779-520
UNII 77TI35393C
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H34Cl2N2O2
CAS Registry Number 34552-83-5
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angioedema10.01.05.009; 22.04.02.008; 23.04.01.001--Not Available
Constipation07.02.02.001--
Discomfort08.01.08.003--Not Available
Dizziness02.11.04.006; 24.06.02.007; 17.02.05.003--
Dry mouth07.06.01.002--
Dyspepsia07.01.02.001--
Erythema multiforme23.03.01.003; 10.01.03.015--
Fatigue08.01.01.002--
Flatulence07.01.04.002--
Headache17.14.01.001--
Hypersensitivity10.01.03.003--
Ileus paralytic07.02.05.001--Not Available
Megacolon07.02.05.002--Not Available
Nausea07.01.07.001--
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Stevens-Johnson syndrome11.07.01.005; 10.01.01.045; 23.03.01.007; 12.03.01.014--
Toxic epidermal necrolysis12.03.01.015; 11.07.01.006; 10.01.01.006; 23.03.01.008--
Urinary retention20.02.02.011--
Urticaria23.04.02.001; 10.01.06.001--
Vomiting07.01.07.003--
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