Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Mercaptopurine
Drug ID BADD_D01392
Description An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Indications and Usage For remission induction and maintenance therapy of acute lymphatic leukemia.
Marketing Status approved
ATC Code L01BB02
DrugBank ID DB01033
KEGG ID D00161; D04931
MeSH ID D015122
PubChem ID 667490
TTD Drug ID D09UZO
NDC Product Code 62991-2899; 69076-913; 15308-0712; 12780-0299; 0054-4581; 0378-3547
UNII E7WED276I5
Synonyms Mercaptopurine | 6H-Purine-6-thione, 1,7-dihydro- | 6-Mercaptopurine Monohydrate | 6 Mercaptopurine Monohydrate | 6-Thiopurine | 6 Thiopurine | 1,7-Dihydro-6H-purine-6-thione | 6-Mercaptopurine | 6 Mercaptopurine | 6-Thiohypoxanthine | 6 Thiohypoxanthine | Purinethol | Puri-Nethol | Mercaptopurina Wellcome | Leupurin | BW 57-323H | BW 57 323H | BW 57323H | Purimethol | Mecaptopurine Anhydrous
Chemical Information
Molecular Formula C5H4N4S
CAS Registry Number 50-44-2
SMILES C1=NC2=C(N1)C(=S)N=CN2
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mucosal inflammation08.01.06.0020.002082%Not Available
Mucous stools07.01.03.006--Not Available
Muscle spasms15.05.03.004--
Muscular weakness17.05.03.005; 15.05.06.001--
Myalgia15.05.02.0010.002810%
Myelodysplastic syndrome16.01.04.001; 01.10.04.0010.001041%
Nasal congestion22.04.04.001--
Nausea07.01.07.0010.014677%
Neoplasm16.16.02.001--Not Available
Neoplasm malignant16.16.01.0010.001041%Not Available
Nephrolithiasis20.04.01.002--
Neutropenia01.02.03.0040.008015%Not Available
Night sweats23.02.03.006; 08.01.03.0310.002290%Not Available
Non-Hodgkin's lymphoma16.35.01.001; 01.17.01.0010.002602%Not Available
Ocular hyperaemia06.04.05.004--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oligospermia21.03.03.005--
Oral candidiasis11.03.03.004; 07.05.07.001--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.0100.004372%
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Palpitations02.11.04.0120.002290%
Pancreatitis07.18.01.0010.009889%
Pancreatitis acute07.18.01.0020.005725%Not Available
Pancreatitis chronic07.18.01.0070.001041%Not Available
Pancytopenia01.03.03.0030.003643%Not Available
Peripheral coldness23.06.04.008; 24.04.03.006; 08.01.09.0100.001561%Not Available
Pleurisy22.05.01.001--Not Available
Portal hypertension24.08.06.001; 09.01.06.0060.007286%
Proctalgia07.03.02.001--
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ADReCS-Target
Drug Name ADR Term Target
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