Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Mexiletine hydrochloride
Drug ID BADD_D01453
Description Antiarrhythmic agent pharmacologically similar to lidocaine. It may have some anticonvulsant properties.
Indications and Usage For the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation.
Marketing Status approved; investigational
ATC Code C01BB02
DrugBank ID DB00379
KEGG ID D00639
MeSH ID D008801
PubChem ID 21467
TTD Drug ID D0X0RI
NDC Product Code 0093-8739; 10135-730; 65977-0122; 31722-036; 31722-037; 51407-381; 63629-1963; 63629-9180; 0527-4108; 0093-8740; 42291-625; 62756-955; 63629-2145; 72162-1784; 82012-029; 0093-8741; 50742-240; 0527-4109; 63629-1964; 63629-9179; 63629-9181; 63629-9290; 0527-4107; 82012-027; 10135-731; 50742-239; 50742-241; 62756-956; 72166-007; 72162-1783; 42291-624; 51407-380; 62559-820; 62559-821; 82012-028; 10135-732; 73435-007; 31722-038; 62559-822; 72162-1782; 53296-0029; 51927-2953; 42291-626; 62756-957; 17511-136; 46708-871; 51407-379
UNII 606D60IS38
Synonyms Mexiletine | Novo-Mexiletine | Novo Mexiletine | Mexiletine Hydrochloride | Mexitil | Mexitil PL | Mexityl | KO-1173 | KO 1173 | KO1173 | KOE-1173 | KOE 1173 | KOE1173 | Mexiletene
Chemical Information
Molecular Formula C11H18ClNO
CAS Registry Number 5370-01-4
SMILES CC1=C(C(=CC=C1)C)OCC(C)N.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic necrosis09.01.07.002--
Hepatitis09.01.07.004--Not Available
Hiccups22.12.01.001; 07.01.06.009--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hypertension24.08.02.001--
Hypoaesthesia23.03.03.081; 17.02.06.023--Not Available
Hypotension24.06.03.002--
Leukopenia01.02.02.001--Not Available
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.04.030--Not Available
Loss of consciousness17.02.04.004--Not Available
Lung infiltration22.01.02.004--Not Available
Malaise08.01.01.003--
Myelofibrosis16.21.03.001; 01.13.03.005--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neutropenia01.02.03.004--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oesophageal ulcer07.04.05.002--
Palpitations02.11.04.012--
Pancreatitis07.18.01.001--
Paraesthesia23.03.03.094; 17.02.06.005--
Peptic ulcer07.04.07.001--Not Available
Pharyngitis22.07.03.004; 11.01.13.003; 07.05.07.004--
Pulmonary fibrosis22.01.02.006--
Pyrexia08.05.02.003--
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