Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Norfloxacin
Drug ID BADD_D01587
Description A synthetic fluoroquinolone (fluoroquinolones) with broad-spectrum antibacterial activity against most gram-negative and gram-positive bacteria. Norfloxacin inhibits bacterial DNA gyrase.
Indications and Usage For the treatment of urinary tract infection
Marketing Status approved
ATC Code J01MA06; S01AE02
DrugBank ID DB01059
KEGG ID D00210
MeSH ID D009643
PubChem ID 4539
TTD Drug ID D0Q2PE
NDC Product Code 53104-7517
UNII N0F8P22L1P
Synonyms Norfloxacin | MK-0366 | MK 0366 | MK-366 | MK 366 | MK0366 | MK366 | Noroxin | AM-0715 | AM 0715 | AM0715 | AM-715 | AM 715
Chemical Information
Molecular Formula C16H18FN3O3
CAS Registry Number 70458-96-7
SMILES CCN1C=C(C(=O)C2=CC(=C(C=C21)N3CCNCC3)F)C(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intracranial pressure increased17.07.02.002--Not Available
Irritability19.04.02.013; 08.01.03.011--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Jaundice cholestatic09.01.01.005--Not Available
Joint stiffness15.01.02.003--Not Available
Lacrimation increased06.08.02.004--
Leukopenia01.02.02.001--Not Available
Liver function test abnormal13.03.04.030--Not Available
Malaise08.01.01.003--
Metabolic acidosis14.01.01.003--Not Available
Mouth ulceration07.05.06.004--Not Available
Muscle disorder15.05.03.014--Not Available
Muscle spasms15.05.03.004--
Myalgia15.05.02.001--
Myasthenia gravis10.04.05.001; 17.05.04.001; 15.05.08.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myoclonus17.02.05.008--Not Available
Nausea07.01.07.001--
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.010--
Nightmare19.02.03.003--Not Available
Nystagmus17.02.02.006; 06.05.02.006--
Oedema14.05.06.010; 08.01.07.006--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain in extremity15.03.04.010--
Palpitations02.11.04.012--
Pancreatitis07.18.01.001--
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