Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Porfimer sodium
Drug ID BADD_D01803
Description The purified component of hematoporphyrin derivative, it consists of a mixture of oligomeric porphyrins. It is used in photodynamic therapy (hematoporphyrin photoradiation); to treat malignant lesions with visible light and experimentally as an antiviral agent. It is the first drug to be approved in the use of photodynamic therapy in the United States.
Indications and Usage Indicated in the treatment of esophageal cancer.
Marketing Status approved; investigational
ATC Code L01XD01
DrugBank ID DB00707
KEGG ID D03327
MeSH ID D017323
PubChem ID 135577896
TTD Drug ID D02JDL
NDC Product Code 76128-155
UNII Y3834SIK5F
Synonyms Dihematoporphyrin Ether | Ether, Dihematoporphyrin | Dihematoporphyrin Ester | Porfimer | DHP Ether | Porfimer Sodium | Photofrin | Photofrin II
Chemical Information
Molecular Formula C68H74N8O11
CAS Registry Number 87806-31-3
SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C(C)O)C)C(=C4C)C(C)OC(C)C6=C(C7=CC 8=C(C(=C(N8)C=C9C(=C(C(=N9)C=C1C(=C(C(=N1)C=C6N7)C)CCC(=O)O)CCC(=O)O)C)C)C(C)O)C )C(=C3CCC(=O)O)C)CCC(=O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Respiratory failure22.02.06.002; 14.01.04.003--
Scab23.03.03.004--Not Available
Sepsis11.01.11.003--
Sinusitis11.01.13.005; 22.07.03.007--
Skin discolouration23.03.03.005--Not Available
Skin disorder23.03.03.007--Not Available
Skin fragility23.03.03.009--Not Available
Skin hyperpigmentation23.05.01.003--
Skin infection11.01.12.003; 23.11.04.007--
Skin lesion23.03.03.010--Not Available
Skin ulcer24.04.03.007; 23.07.03.003--
Skin wrinkling23.01.03.001--Not Available
Stridor22.04.02.003--
Supraventricular tachycardia02.03.03.012--
Swelling08.01.03.015--Not Available
Tachycardia02.03.02.007--Not Available
Tinnitus17.04.07.004; 04.04.01.002--
Tracheo-oesophageal fistula22.04.07.003; 07.11.05.003; 03.16.02.002--Not Available
Tremor17.01.06.002--
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria10.01.06.001; 23.04.02.001--
Vitiligo23.05.02.004; 10.04.02.004--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Wheezing22.03.01.009--
Joint range of motion decreased15.01.02.006--
Scar pain23.03.03.060--Not Available
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