| Drug Name |
Pramipexole dihydrochloride |
| Drug ID |
BADD_D01818 |
| Description |
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is a _non-ergot dopamine agonist_ drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement) [A176867]. It was first approved by the FDA in 1997 [L5882]. Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients [A176855], leading to increased difficulty in performing activities of daily living due to symptoms that progress over time [A176858]. The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 2016 [A176861]. This increase may be attributed to an aging population along with other contributing factors [A176861].
In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS) [A176873]. RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs [A176876]. |
| Indications and Usage |
This drug is indicated for the symptomatic treatment of Parkinson’s disease [FDA label]. This drug can be administered as monotherapy or in conjunction with levodopa. It is also indicated for symptomatic treatment of moderate to severe primary Restless Legs Syndrome (RLS) [FDA label]. |
| Marketing Status |
approved; investigational |
| ATC Code |
N04BC05 |
| DrugBank ID |
DB00413
|
| KEGG ID |
D00559
|
| MeSH ID |
D000077487
|
| PubChem ID |
119569
|
| TTD Drug ID |
D0G8NN
|
| NDC Product Code |
82245-0120; 33342-210; 33342-211; 46708-003; 57237-183; 64380-748; 65862-604; 68382-196; 70771-1334; 29300-208; 33342-208; 33342-213; 46708-580; 50090-2455; 50228-126; 50228-128; 50742-332; 50742-337; 57237-180; 57237-185; 60429-086; 62332-006; 62332-007; 62332-160; 65841-735; 70771-1329; 70771-1331; 71335-1877; 0597-0115; 53104-7589; 65085-0056; 13668-091; 13668-093; 46708-007; 46708-574; 55111-611; 55111-615; 57237-184; 62332-156; 63629-5042; 64380-751; 68382-874; 68382-875; 69680-145; 70771-1328; 70771-1332; 71335-0584; 60429-085; 60687-592; 65862-606; 68382-474; 68462-331; 68462-332; 71335-1504; 0597-0286; 0904-6704; 65862-605; 16714-916; 16714-918; 29300-207; 50228-131; 60429-089; 60687-581; 64380-747; 64380-750; 65841-734; 65841-738; 68382-478; 68462-330; 68462-333; 0597-0285; 14501-0052; 49706-1868; 65862-607; 13668-184; 16714-919; 16714-922; 33342-212; 50090-3280; 50228-127; 55111-613; 65841-844; 65862-609; 68382-197; 13668-092; 13668-095; 29300-211; 46708-004; 46708-575; 50742-333; 57237-181; 60429-090; 62332-003; 63629-8289; 64380-746; 68462-627; 69680-146; 71335-1537; 71335-2167; 0597-0287; 65089-0040; 65862-506; 65862-608; 16714-917; 29300-270; 33342-209; 46708-005; 46708-578; 50742-331; 55111-612; 55111-614; 60429-087; 60687-570; 62332-005; 70771-1330; 0597-0109; 0597-0113; 65977-0021; 29300-209; 50228-129; 50228-130; 62332-154; 62332-157; 62332-158; 62332-159; 65841-736; 68382-198; 68382-199; 68382-440; 68382-475; 68382-477; 68462-334; 70771-1333; 71034-003; 16714-920; 46708-576; 50090-5036; 50742-336; 62332-004; 62332-155; 64380-749; 65841-737; 68382-200; 68382-476; 71034-002; 71335-1808; 0597-0116; 13668-094; 29300-210; 33342-214; 46708-006; 46708-577; 46708-579; 50742-334; 50742-335; 57237-182 |
| UNII |
3D867NP06J
|
| Synonyms |
Pramipexole | 4,5,6,7-Tetrahydro-N6-propyl-2,6-benzothiazole-diamine | Pramipexol | 2-Amino-4,5,6,7-tetrahydro-6-propylaminobenzothiazole | Dexpramipexole | Pramipexol, (R)-isomer | Mirapex | Pramipexol Dihydrobromide, (+-)-isomer | Pramipexol Dihydrochloride, (S)-isomer | Pramipexole Dihydrochloride Anhydrous | Sifrol | SND 919CL2x | SND919CL2x | SND-919CL2x | SND-919 | SND 919 | KNS 760704 | KNS760704 | KNS-760704 | Pramipexol, (+-)-isomer | Pramipexole Dihydrochloride | Pramipexole Hydrochloride Monohydrate | 2-Amino-6-propylaminotetrahydrobenzothiazole | 2 Amino 6 propylaminotetrahydrobenzothiazole | 6,7-Tetrahydro-N6-propyl-2,6-benzothiazolediamine dihydrochloride monohydrate |
