Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Procarbazine hydrochloride
Drug ID BADD_D01847
Description An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.
Indications and Usage For use with other anticancer drugs for the treatment of stage III and stage IV Hodgkin's disease.
Marketing Status approved; investigational
ATC Code L01XB01
DrugBank ID DB01168
KEGG ID D00478
MeSH ID D011344
PubChem ID 9703
TTD Drug ID D08GYO
NDC Product Code 48087-0085; 14096-128; 54482-054; 48087-0050
UNII XH0NPH5ZX8
Synonyms Procarbazine | Procarbazine Monohydrobromide | Monohydrobromide, Procarbazine | Procarbazine Hydrochloride | Hydrochloride, Procarbazine | Procarbazine Monohydrochloride | Monohydrochloride, Procarbazine | Matulane | Natulan
Chemical Information
Molecular Formula C12H19N3O.ClH
CAS Registry Number 366-70-1
SMILES CC(C)NC(=O)C1=CC=C(C=C1)CNNC.Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematemesis07.12.02.002; 24.07.02.011--Not Available
Haematuria21.10.01.018; 24.07.01.047; 20.02.01.006--
Haemolytic anaemia01.06.03.002--Not Available
Haemoptysis02.11.04.009; 24.07.01.006; 22.02.03.004--Not Available
Hallucination19.10.04.003--
Headache17.14.01.001--
Hepatic function abnormal09.01.02.001--Not Available
Herpes virus infection11.05.02.008--Not Available
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypersensitivity10.01.03.003--
Hyporeflexia17.02.01.003--
Hypotension24.06.03.002--
Infection11.01.08.002--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Jaundice23.03.03.030; 09.01.01.004; 01.06.04.004--Not Available
Lethargy17.02.04.003; 08.01.01.008; 19.04.04.004--
Leukopenia01.02.02.001--Not Available
Melaena24.07.02.013; 07.12.02.004--Not Available
Myalgia15.05.02.001--
Myelofibrosis01.13.03.005; 16.21.03.001--Not Available
Nausea07.01.07.001--
Neoplasm malignant16.16.01.001--Not Available
Nervousness19.06.02.003--Not Available
Neuropathy peripheral17.09.03.003--Not Available
Nightmare19.02.03.003--Not Available
Nocturia20.02.03.001--Not Available
Nystagmus06.05.02.006; 17.02.02.006--
Oedema08.01.07.006; 14.05.06.010--Not Available
Pancytopenia01.03.03.003--Not Available
Papilloedema24.03.07.001; 17.07.02.004; 06.09.02.002--
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