Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Rasburicase
Drug ID BADD_D01917
Description Rasburicase is a recombinant urate-oxidase enzyme produced by a genetically modified Saccharomyces cerevisiae strain. The cDNA coding for rasburicase was cloned from a strain of _Aspergillus flavus_.
Indications and Usage For treatment of hyperuricemia, reduces elevated plasma uric acid levels (from chemotherapy)
Marketing Status approved; investigational
ATC Code V03AF07
DrugBank ID DB00049
KEGG ID D05704
MeSH ID C469709
PubChem ID Not Available
TTD Drug ID D08LJP
NDC Product Code 0024-5151; 0024-5150
UNII 08GY9K1EUO
Synonyms rasburicase | Elitek | Fasturtec
Chemical Information
Molecular Formula Not Available
CAS Registry Number 134774-45-1
SMILES Not Available
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Alanine aminotransferase increased13.03.04.005--
Anxiety19.06.02.002--
Arrhythmia supraventricular02.03.03.001--Not Available
Arthralgia15.01.02.001--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Gastrointestinal infection11.01.07.012; 07.19.02.005--Not Available
Headache17.14.01.001--
Hyperbilirubinaemia14.11.01.010; 09.01.01.003; 01.06.04.003--Not Available
Hyperphosphataemia14.04.03.007--
Hypersensitivity10.01.03.003--
Hyperuricaemia14.09.01.003--
Hypervolaemia02.05.04.019; 14.05.06.003--Not Available
Hypophosphataemia14.04.03.001--
Injection site irritation12.07.03.027; 08.02.03.027--Not Available
Laryngeal pain22.12.03.010--
Leukaemia16.01.03.001; 01.10.03.001--
Lymphoma16.20.01.001; 01.12.01.001--Not Available
Mucosal inflammation08.01.06.002--Not Available
Myocardial ischaemia24.04.04.010; 02.02.02.008--Not Available
Nausea07.01.07.001--
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Pulmonary haemorrhage22.12.01.009; 24.07.01.016--
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Sepsis11.01.11.003--
Tumour lysis syndrome16.32.03.002; 14.05.01.004--
Vomiting07.01.07.003--
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ADReCS-Target
Drug Name ADR Term Target
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