Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Sertraline
Drug ID BADD_D02010
Description Sertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects. Several weeks of therapy with sertraline may be required before beneficial effects are noticed. Sertraline displays enhanced safety or tolerability than other classes of antidepressants, which frequently cause high levels of drowsiness, dizziness, blurred vision, and other undesirable effects.[A1846,A187075,T28]
Indications and Usage Sertraline is indicated for the management of major depressive disorder (MDD), post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), panic disorder (PD), premenstrual dysphoric disorder (PMDD), and social anxiety disorder (SAD).[L9016] Common off-label uses for sertraline include the prevention of post stroke depression[A187078], generalized anxiety disorder (GAD), fibromyalgia, premature ejaculation, migraine prophylaxis, diabetic neuropathy, and neurocardiogenic syncope.[L5227]
Marketing Status approved
ATC Code N06AB06
DrugBank ID DB01104
KEGG ID D02360
MeSH ID D020280
PubChem ID 68617
TTD Drug ID D0K0TC
NDC Product Code 76282-214; 23155-759; 68180-353; 55700-225; 63187-055; 70518-0153; 70518-1461; 70518-1617; 71335-9714; 0615-7990; 65427-009; 55154-3570; 0615-7991; 76282-212; 0904-6924; 50090-5848; 70518-1040; 23155-757; 70518-2512; 0904-6925; 68180-351; 68180-352; 68071-4400; 63187-212; 68788-7329; 0615-7989; 0904-6926; 55154-3569; 63187-478; 67296-1199; 70934-958; 76282-213; 23155-758; 50090-0989
UNII QUC7NX6WMB
Synonyms Sertraline | Zoloft | Altruline | Lustral | Apo-Sertraline | Apo Sertraline | Aremis | Besitran | Sealdin | Gladem | Novo-Sertraline | Novo Sertraline | ratio-Sertraline | ratio Sertraline | Rhoxal-sertraline | Rhoxal sertraline | Sertraline Hydrochloride | Hydrochloride, Sertraline | Sertraline Hydrochloride (1S-cis)-Isomer | Gen-Sertraline | Gen Sertraline
Chemical Information
Molecular Formula C17H17Cl2N
CAS Registry Number 79617-96-2
SMILES CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Postmenopausal haemorrhage24.07.03.002; 21.02.01.0020.000019%Not Available
Parkinsonian gait17.01.05.005; 08.01.02.0050.000045%Not Available
Fluid intake reduced14.05.10.0010.000013%Not Available
Painful erection21.03.01.0090.000013%Not Available
Food craving19.09.01.010; 14.03.01.0090.000013%Not Available
Cutaneous lupus erythematosus23.03.02.008; 15.06.02.007; 10.04.03.0070.000013%Not Available
Colitis microscopic07.08.01.0110.000643%Not Available
Rectal tenesmus15.05.03.011; 07.03.03.001--Not Available
Neonatal tachypnoea22.11.01.003; 18.04.09.0030.000025%Not Available
Hypoaesthesia oral17.02.06.021; 07.05.05.0030.000166%Not Available
Paraesthesia oral07.05.05.035; 17.02.06.0080.000098%Not Available
Anxiety disorder19.06.01.0020.000032%Not Available
Bipolar disorder19.16.01.0030.000083%Not Available
Cognitive disorder19.21.02.001; 17.03.03.0030.000312%
Female sexual dysfunction21.03.02.004; 19.08.05.001--Not Available
Male sexual dysfunction19.08.05.003; 21.03.02.0120.000051%Not Available
Major depression19.15.01.0030.000064%Not Available
Toxic skin eruption10.01.01.008; 12.03.01.073; 23.03.05.0030.000051%Not Available
Metabolic disorder14.11.01.0010.000028%Not Available
Dyslipidaemia14.08.04.0150.000032%Not Available
Cystoid macular oedema12.02.02.005; 06.04.06.0100.000038%Not Available
Dysgraphia17.02.03.0060.000032%Not Available
Retroperitoneal haematoma24.07.01.060; 07.07.02.0050.000013%Not Available
Aortic disorder24.03.04.0040.000025%Not Available
Vasodilation procedure25.03.01.001--Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.000228%Not Available
Disturbance in sexual arousal19.08.04.0030.000064%Not Available
Cerebral vasoconstriction24.04.06.025; 17.08.02.0120.000013%Not Available
Epidermal necrosis23.03.03.0350.000013%Not Available
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.0270.000363%
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ADReCS-Target
Drug Name ADR Term Target
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