| Pharmaceutical Information |
| Drug Name |
Strontium chloride sr-89 |
| Drug ID |
BADD_D02075 |
| Description |
Strontium chloride (Sr-89), initially FDA-approved in 1993, is used as a paliative therapeutic option to help relieve the pain from bone metastases. Strontium chloride is mainly used in cases of metastatic castrate-resistant prostate cancer.[A31264] Bone metastases is a common and severe complication presented in advanced stages of the disease. It is usually presented mainly in patients with prostatic and breast cancer, as well as in cancer of lung, bladder and thyroid. There has been some cases of apparent tumor regression which has given it a potential tumoricidal effect.[A31263] |
| Indications and Usage |
Strontium-89 Chloride Injection is indicated as a paliative for the relief of bone pain in patients with skeletal metastases. It is impotant to confirm the presence of bone metastases prior the beginning of therapy.[A31264] |
| Marketing Status |
approved; investigational |
| ATC Code |
Not Available |
| DrugBank ID |
DB09498
|
| KEGG ID |
D02006
|
| MeSH ID |
C025700
|
| PubChem ID |
5388879
|
| TTD Drug ID |
D0R6HN
|
| NDC Product Code |
72928-089 |
| UNII |
5R78837D4A
|
| Synonyms |
strontium chloride | strontium chloride hexahydrate | strontium chloride, disodium salt | strontium chloride, 85Sr-labeled | strontium chloride Sr 85 | strontium chloride, 89Sr-labeled | strontium chloride Sr 89 | strontium-89 chloride | strontium chloride, 90Sr-labeled | Metastron | strontium chloride monohydrate |
|
| Chemical Information |
| Molecular Formula |
Cl2Sr |
| CAS Registry Number |
38270-90-5 |
| SMILES |
[Cl-].[Cl-].[Sr+2] |
| Chemical Structure |
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| ADRs Induced by Drug |
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*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
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| ADR Term |
ADReCS ID |
ADR Frequency (FAERS)
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ADR Severity Grade (FAERS)
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ADR Severity Grade (CTCAE)
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| Bone pain | 15.02.01.001 | - | - | | | Chills | 15.05.03.016; 08.01.09.001 | - | - | | | Death | 08.04.01.001 | - | - | | | Leukopenia | 01.02.02.001 | - | - | Not Available | | Pyrexia | 08.05.02.003 | - | - | | | Sepsis | 11.01.11.003 | - | - | | | Hot flush | 24.03.01.005; 21.02.02.001; 08.01.03.027 | - | - | | | Myelosuppression | 01.03.03.015 | - | - | Not Available |
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