Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tafluprost
Drug ID BADD_D02108
Description A prostaglandin analogue ester prodrug used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. Chemically, tafluprost is a fluorinated analog of prostaglandin F2-alpha. Tafluprost was approved for use in the U.S. on February 10, 2012.
Indications and Usage Tafluprost is indicated for reducing elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Marketing Status approved
ATC Code S01EE05
DrugBank ID DB08819
KEGG ID D06274
MeSH ID C485333
PubChem ID 9868491
TTD Drug ID D04LCQ
NDC Product Code 82584-609; 61556-080; 65035-137; 54893-0021; 63190-0590; 76397-013; 65302-062; 68245-0012; 75872-0001; 66993-429; 0781-6184; 70390-0001; 17478-609
UNII 1O6WQ6T7G3
Synonyms tafluprost | 1-methylethyl (5Z)-7-((1R,2R, 3R,5S)-2-((1E)-3,3-difluoro-4-phenoxy -1-butenyl)-3,5-dihydroxycyclopentyl)-5-heptenoate | AFP-168
Chemical Information
Molecular Formula C25H34F2O5
CAS Registry Number 209860-87-7
SMILES CC(C)OC(=O)CCCC=CCC1C(CC(C1C=CC(COC2=CC=CC=C2)(F)F)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal sensation in eye06.01.01.0010.000913%Not Available
Alopecia23.02.02.0010.000365%
Arthralgia15.01.02.0010.000527%
Asthma22.03.01.002; 10.01.03.010--Not Available
Bladder cancer16.08.01.001; 20.03.04.0010.000107%Not Available
Blepharal pigmentation23.05.01.009; 06.06.04.0140.000107%Not Available
Blepharitis23.03.04.012; 06.04.04.0010.000236%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000107%Not Available
Cardiac failure congestive02.05.01.0020.000107%Not Available
Cataract06.06.01.001--
Conjunctivitis allergic10.01.04.002; 06.04.01.003--Not Available
Cough22.02.03.0010.000548%
Death08.04.01.0010.001343%
Drug ineffective08.06.01.0060.003288%Not Available
Dry eye06.08.02.0010.001096%
Dysgeusia17.02.07.003; 07.14.03.0010.000419%
Dyspnoea02.11.05.003; 22.02.01.004--
Endophthalmitis06.04.05.009; 11.01.06.003--
Erythema23.03.06.0010.000473%Not Available
Erythema of eyelid23.03.06.006; 06.04.04.0030.000731%Not Available
Eye discharge06.04.05.0010.000913%Not Available
Eye disorder06.08.03.001--Not Available
Eye haemorrhage24.07.05.002; 06.07.02.001; 12.02.02.0120.000236%Not Available
Eye inflammation06.04.05.0020.000365%Not Available
Eye irritation06.04.05.0030.007308%Not Available
Eye pain06.08.03.0020.004546%
Eye swelling06.08.03.0030.001569%Not Available
Eyelid oedema23.04.01.003; 10.01.05.001; 06.04.04.004--Not Available
Headache17.14.01.0010.002278%
Iritis10.02.01.022; 06.04.03.002--Not Available
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